Structure of PDB 1k22 Chain H Binding Site BS04
Receptor Information
>1k22 Chain H (length=251) Species:
9606
(Homo sapiens) [
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IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETGQP
SVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGG
PFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQF
G
Ligand information
Ligand ID
NA
InChI
InChI=1S/Na/q+1
InChIKey
FKNQFGJONOIPTF-UHFFFAOYSA-N
SMILES
Software
SMILES
ACDLabs 10.04
CACTVS 3.341
OpenEye OEToolkits 1.5.0
[Na+]
Formula
Na
Name
SODIUM ION
ChEMBL
DrugBank
DB14516
ZINC
PDB chain
1k22 Chain H Residue 392 [
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Receptor-Ligand Complex Structure
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PDB
1k22
Factorising ligand affinity: a combined thermodynamic and crystallographic study of trypsin and thrombin inhibition.
Resolution
1.93 Å
Binding residue
(original residue number in PDB)
K169 D170 T172
Binding residue
(residue number reindexed from 1)
K167 D168 T170
Annotation score
3
Enzymatic activity
Enzyme Commision number
3.4.21.5
: thrombin.
Gene Ontology
Molecular Function
GO:0004252
serine-type endopeptidase activity
GO:0005509
calcium ion binding
Biological Process
GO:0006508
proteolysis
GO:0007596
blood coagulation
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Molecular Function
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Biological Process
External links
PDB
RCSB:1k22
,
PDBe:1k22
,
PDBj:1k22
PDBsum
1k22
PubMed
11676542
UniProt
P00734
|THRB_HUMAN Prothrombin (Gene Name=F2)
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