Structure of PDB 8bed Chain G Binding Site BS04

Receptor Information
>8bed Chain G (length=687) Species: 3702 (Arabidopsis thaliana) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RNPVGGARVHFSNPEDAIEVFVDGYAVKVPKGFTVLQACEVAGVDIPRFC
YHSRLSIAGNCRMCLVEVEKSPKPVASCAMPALPGMKIKTDTPIAKKARE
GVMEFLLMNHPLDCPICDQGGECDLQDQSMAFGSDRGRFTEMKRSVVDKN
LGPLVKTVMTRCIQCTRCVRFASEVAGVQDLGILGRGSGEEIGTYVEKLM
TSELSGNVIDICPVGALTSKPFAFKARNWELKATETIDVSDAVGSNIRVD
SRGPEVMRIIPRLNEDINEEWISDKTRFCYDGLKRQRLSDPMIRDSDGRF
KAVSWRDALAVVGDIIHQVKPDEIVGVAGQLSDAESMMVLKDFVNRMGSD
NVWCEGTAAGVDADLRYSYLMNTSISGLENADLFLLIGTQPRVEAAMVNA
RICKTVRASNAKVGYVGPPAEFNYDCKHLGTGPDTLKEIAEGRHPFCTAL
KNAKNPAIIVGAGLFNRTDKNAILSSVESIAQANNVVRPDWNGLNFLLQY
AAQAAALDLGLIQQSAKALESAKFVYLMGADDVNVDKIPKDAFVVYQGHH
GDKAVYRANVILPASAFTEKEGTYENTEGFTQQTVPAVPTVGDARDDWKI
VRALSEVSGVKLPYNSIEGVRSRIKSVAPNLVHTDEREPAAFGPSLKPEC
KEAMSTTPFQTVVENFYMTNSITRASKIMAQCSAVLL
Ligand information
Ligand IDSF4
InChIInChI=1S/4Fe.4S
InChIKeyLJBDFODJNLIPKO-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 2.0.7[S]12[Fe]3[S]4[Fe]1[S]5[Fe]2[S]3[Fe]45
CACTVS 3.385S1[Fe]S[Fe]1.S2[Fe]S[Fe]2
FormulaFe4 S4
NameIRON/SULFUR CLUSTER
ChEMBL
DrugBank
ZINC
PDB chain8bed Chain G Residue 802 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB8bed Cryo-EM structure of the respiratory I + III 2 supercomplex from Arabidopsis thaliana at 2 angstrom resolution.
Resolution2.03 Å
Binding residue
(original residue number in PDB)		H166 D169 C170 C173 Q175 G176 C179 L181 Q182 V270
Binding residue
(residue number reindexed from 1)		H110 D113 C114 C117 Q119 G120 C123 L125 Q126 V214
Annotation score1
Enzymatic activity
Enzyme Commision number 7.1.1.2: NADH:ubiquinone reductase (H(+)-translocating).
Gene Ontology
Molecular Function
GO:0008137 NADH dehydrogenase (ubiquinone) activity
GO:0016491 oxidoreductase activity
GO:0016651 oxidoreductase activity, acting on NAD(P)H
GO:0046872 metal ion binding
GO:0051536 iron-sulfur cluster binding
GO:0051537 2 iron, 2 sulfur cluster binding
GO:0051539 4 iron, 4 sulfur cluster binding
Biological Process
GO:0009853 photorespiration
GO:0042773 ATP synthesis coupled electron transport
GO:1902600 proton transmembrane transport
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0009507 chloroplast
GO:0009536 plastid
GO:0016020 membrane
GO:0031966 mitochondrial membrane
GO:0045271 respiratory chain complex I

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8bed, PDBe:8bed, PDBj:8bed
PDBsum8bed
PubMed36585502
UniProtQ9FGI6|NDUS1_ARATH NADH dehydrogenase [ubiquinone] iron-sulfur protein 1, mitochondrial (Gene Name=EMB1467)

[Back to BioLiP]