Structure of PDB 7zi4 Chain G Binding Site BS04

Receptor Information
>7zi4 Chain G (length=682) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LKGYQLKGMNWLANLYEQGINGILADEMGLGKTVQSIALLAHLAERENIW
GPFLIISPASTLNNWHQEFTRFVPKFKVLPYWGNPHDRKVIRRFWSAPFH
VVITSYQLVVQDVKYFQRVKWQYMVLDEAQALKSSSSVRWKILLQFQCRN
RLLLTGTPIQNTMAELWALLHFIMPTLFDSHEEFNEWENQLSRLHMILKP
FMLRRIKKDVENELSDKIEILMYCQLTSRQKLLYQALKNLVMQFRKVCNH
PELFERQETWSPFHISLKPYHISKFIYRHGQIRVFNHSRDRWLRVLSPFA
PDYIQRSLFHRKGINEESCFSFLRFIDISPAEMANLMLQGLLARWLALFL
SLKASYRLHQLRSWGAPEGESHQRYLRNKDFLLGVNFPLSFPNLCSCPLL
KSLVFSSHCKAVSGYSDQVVHQRRSATSSLRRCLLTELPSFLCVASPRVT
AVPLDSYCNDRSAEYERRVLKEGGSLAAKQCLLNGAPELAADWLNRRSQF
FPEPAGGLWSIRPQNGWSFIRIPGKESLITDSGKLYALDVLLTRLKSQGH
RVLIYSQMTRMIDLLEEYMVYRKHTYMRLDGSSKISERRDMVADFQNRND
IFVFLLSTRAGGLGINLTAADTVIFYDSDWNPTVDQQAMDRAHRLGQTKQ
VTVYRLICKGTIEERILQRAKEKSEIQRMVIS
Ligand information
Ligand IDBEF
InChIInChI=1S/Be.3FH/h;3*1H/q+2;;;/p-3
InChIKeyOGIAHMCCNXDTIE-UHFFFAOYSA-K
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0[Be-](F)(F)F
ACDLabs 10.04
CACTVS 3.341		F[Be-](F)F
FormulaBe F3
NameBERYLLIUM TRIFLUORIDE ION
ChEMBL
DrugBank
ZINC
PDB chain7zi4 Chain G Residue 1602 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7zi4 Cryo-EM structure of the human INO80 complex bound to a WT nucleosome
Resolution3.2 Å
Binding residue
(original residue number in PDB)		M545 G1182 R1212
Binding residue
(residue number reindexed from 1)		M28 G614 R644
Annotation score1
Enzymatic activity
Enzyme Commision number 3.6.4.-
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003779 actin binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008094 ATP-dependent activity, acting on DNA
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0042393 histone binding
GO:0043014 alpha-tubulin binding
GO:0140658 ATP-dependent chromatin remodeler activity
Biological Process
GO:0000070 mitotic sister chromatid segregation
GO:0000723 telomere maintenance
GO:0000724 double-strand break repair via homologous recombination
GO:0006275 regulation of DNA replication
GO:0006281 DNA repair
GO:0006282 regulation of DNA repair
GO:0006302 double-strand break repair
GO:0006310 DNA recombination
GO:0006338 chromatin remodeling
GO:0006351 DNA-templated transcription
GO:0010571 positive regulation of nuclear cell cycle DNA replication
GO:0030307 positive regulation of cell growth
GO:0033044 regulation of chromosome organization
GO:0034644 cellular response to UV
GO:0045739 positive regulation of DNA repair
GO:0045893 positive regulation of DNA-templated transcription
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0045995 regulation of embryonic development
GO:0051225 spindle assembly
GO:0051301 cell division
GO:0051726 regulation of cell cycle
GO:0060382 regulation of DNA strand elongation
GO:0070914 UV-damage excision repair
GO:0071479 cellular response to ionizing radiation
GO:1904507 positive regulation of telomere maintenance in response to DNA damage
GO:2000045 regulation of G1/S transition of mitotic cell cycle
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0005737 cytoplasm
GO:0005819 spindle
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005874 microtubule
GO:0016604 nuclear body
GO:0031011 Ino80 complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7zi4, PDBe:7zi4, PDBj:7zi4
PDBsum7zi4
PubMed
UniProtQ9ULG1|INO80_HUMAN Chromatin-remodeling ATPase INO80 (Gene Name=INO80)

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