Structure of PDB 7p7m Chain G Binding Site BS04

Receptor Information
>7p7m Chain G (length=905) Species: 469008 (Escherichia coli BL21(DE3)) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ATIHVDGKEYEVNGADNLLEACLSLGLDIPYFCWHPALGSVGACRQCAVK
QYQNAEDTRGRLVMSCMTPASDGTFISIDDEEAKQFRESVVEWLMTNHPH
DCPVCEEGGNCHLQDMTVMTGHSFRRYRFTKRTHRNQDLGPFISHEMNRC
IACYRCVRYYKDYAGGTDLGVYGAHDNVYFGRPEDGTLESEFSGNLVEIC
PTGVFTDKTHSERYNRKWDMQFAPSICQQCSIGCNISPGERYGELRRIEN
RYNGTVNHYFLCDRGRFGYGYVNLKDRPRQPVQRRGDDFITLNAEQAMQG
AADILRQSKKVIGIGSPRASVESNFALRELVGEENFYTGIAHGEQERLQL
ALKVLREGGIYTPALREIESYDAVLVLGEDVTQTGARVALAVRQAVKGKA
REMAAAQKVADWQIAAILNIGQRAKHPLFVTNVDDTRLDDIAAWTYRAPV
EDQARLGFAIAHALDNSAPAVDGIEPELQSKIDVIVQALAGAKKPLIISG
TNAGSLEVIQAAANVAKALKGRGADVGITMIARSVNSMGLGIMGGGSLEE
ALTELETGRADAVVVLENDLHRHASATRVNAALAKAPLVMVVDHQRTAIM
ENAHLVLSAASFAESDGTVINNEGRAQRFFQVYDPAYYDSKTVMLESWRW
LHSLHSTLLSREVDWTQLDHVIDAVVAKIPELAGIKDAAPDATFRIRGQK
LAREPHRYSGRTAMRANISVHEPRQPQDIDTMFTFSMEGNNQPTAHRSQV
PFAWAPGWNSPQAWNKFQDEVGGKLRFGDPGVRLFETSENGLDYFTSVPA
RFQPQDGKWRIAPYYHLFGSDELSQRAPVFQSRMPQPYIKLNPADAAKLG
VNAGTRVSFSYDGNTVTLPVEIAEGLTAGQVGLPMGMSGIAPVLAGAHLE
DLKEA
Ligand information
Ligand IDFES
InChIInChI=1S/2Fe.2S
InChIKeyNIXDOXVAJZFRNF-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04[Fe]1S[Fe]S1
CACTVS 3.341
OpenEye OEToolkits 1.5.0		S1[Fe]S[Fe]1
FormulaFe2 S2
NameFE2/S2 (INORGANIC) CLUSTER
ChEMBL
DrugBank
ZINC
PDB chain7p7m Chain G Residue 1004 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7p7m A universal coupling mechanism of respiratory complex I.
Resolution3.2 Å
Binding residue
(original residue number in PDB)		C36 W37 G45 C47 R48 C50 M67 C69
Binding residue
(residue number reindexed from 1)		C33 W34 G42 C44 R45 C47 M64 C66
Annotation score1
Enzymatic activity
Enzyme Commision number 7.1.1.-
Gene Ontology
Molecular Function
GO:0003954 NADH dehydrogenase activity
GO:0005515 protein binding
GO:0008137 NADH dehydrogenase (ubiquinone) activity
GO:0010181 FMN binding
GO:0016491 oxidoreductase activity
GO:0016651 oxidoreductase activity, acting on NAD(P)H
GO:0043546 molybdopterin cofactor binding
GO:0046872 metal ion binding
GO:0048038 quinone binding
GO:0051536 iron-sulfur cluster binding
GO:0051537 2 iron, 2 sulfur cluster binding
GO:0051539 4 iron, 4 sulfur cluster binding
Biological Process
GO:0009060 aerobic respiration
GO:0022904 respiratory electron transport chain
GO:0042773 ATP synthesis coupled electron transport
GO:0045333 cellular respiration
GO:1902600 proton transmembrane transport
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0030964 NADH dehydrogenase complex
GO:0045271 respiratory chain complex I
GO:1990204 oxidoreductase complex

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7p7m, PDBe:7p7m, PDBj:7p7m
PDBsum7p7m
PubMed36104567
UniProtP33602|NUOG_ECOLI NADH-quinone oxidoreductase subunit G (Gene Name=nuoG)

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