Structure of PDB 7c2h Chain G Binding Site BS04

Receptor Information

>7c2h Chain G (length=197) Species: 1706445 (Candidatus Thorarchaeota archaeon SMTZ1-83) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

REPTVYHIQKGRLVKMKDPGAFGRGDCYLVDAGMKIYLWIGPKSTVDEKF
LTAATAVMSDQSREGKADIDRIDGGNEPAEFKALFDDFCLTDEDTEGILK
KVQMETHEHRLWRVHREGDETFFAEVDLNKNSLKSDDVYLLDAWDDIWVW
RGKDATAREKFDGNILARRYDAERVGVQEIEIIEEGQEPEEFFKSFP

Ligand information

Ligand ID

InChI

InChI=1S/Ca/q+2

InChIKey

BHPQYMZQTOCNFJ-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Ca++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Ca+2]

Formula

Name

CALCIUM ION

PDB chain

7c2h Chain G Residue 305 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	7c2h Insights into the evolution of regulated actin dynamics via characterization of primitive gelsolin/cofilin proteins from Asgard archaea
Resolution	2.352 Å
Binding residue (original residue number in PDB)	D172 R175 G177 Q179
Binding residue (residue number reindexed from 1)	D171 R174 G176 Q178
Annotation score	4

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0005546	phosphatidylinositol-4,5-bisphosphate binding
GO:0046872	metal ion binding
GO:0051015	actin filament binding

	Biological Process
GO:0008154	actin polymerization or depolymerization
GO:0051014	actin filament severing
GO:0051016	barbed-end actin filament capping

	Cellular Component
GO:0005737	cytoplasm
GO:0015629	actin cytoskeleton

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Molecular Function

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Cellular Component

External links

PDB	RCSB:7c2h, PDBe:7c2h, PDBj:7c2h
PDBsum	7c2h
PubMed
UniProt	A0A135VDL7

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