Structure of PDB 6sgb Chain FF Binding Site BS04

Receptor Information
>6sgb Chain FF (length=408) Species: 5702 (Trypanosoma brucei brucei) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MKRIVVPHRWSEMNRVEHPPLMMKQLFQGVCGGLRWLETKSLAQYLAVRA
IEEGYPSTPGVRSLQVTKQKRLVSYDVLDCTLGSGYHAGAVLENGGPYTR
VVALDCDHDAMHAARDLVEEFGGDRFRFYCCKMSEAKAMFGERSFDAIMI
DGGVSDTQLEDPERGFLLDDEGGHRLDMRFGPQMGVGALEYLNTVSQHTL
VSSLLAYGLLEYGQAMKMSRAITRRKPFVDSREVLTCIEQAGDELPEGGW
RSQGSRRKSPMSWKFLTSLRCIINNEMYELRQGIENALLMLRDDGRLVVF
SRLPWEERLVRGTVDDHPHALLSYVEDISIDDVQIYGFTRHAKMWVITRA
ASSAYALKNTTTLTEEKFRESSVRWLTGMYAGQTHGFPANNFTFENFERK
EWVTLRRN
Ligand information
Ligand IDSAH
InChIInChI=1S/C14H20N6O5S/c15-6(14(23)24)1-2-26-3-7-9(21)10(22)13(25-7)20-5-19-8-11(16)17-4-18-12(8)20/h4-7,9-10,13,21-22H,1-3,15H2,(H,23,24)(H2,16,17,18)/t6-,7+,9+,10+,13+/m0/s1
InChIKeyZJUKTBDSGOFHSH-WFMPWKQPSA-N
SMILES
SoftwareSMILES
CACTVS 3.341N[CH](CCSC[CH]1O[CH]([CH](O)[CH]1O)n2cnc3c(N)ncnc23)C(O)=O
OpenEye OEToolkits 1.5.0c1nc(c2c(n1)n(cn2)C3C(C(C(O3)CSCCC(C(=O)O)N)O)O)N
CACTVS 3.341N[C@@H](CCSC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n2cnc3c(N)ncnc23)C(O)=O
ACDLabs 10.04O=C(O)C(N)CCSCC3OC(n2cnc1c(ncnc12)N)C(O)C3O
OpenEye OEToolkits 1.5.0c1nc(c2c(n1)n(cn2)[C@H]3[C@@H]([C@@H]([C@H](O3)CSCC[C@@H](C(=O)O)N)O)O)N
FormulaC14 H20 N6 O5 S
NameS-ADENOSYL-L-HOMOCYSTEINE
ChEMBLCHEMBL418052
DrugBankDB01752
ZINCZINC000004228232
PDB chain6sgb Chain FF Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6sgb Mitoribosomal small subunit biogenesis in trypanosomes involves an extensive assembly machinery.
Resolution3.3 Å
Binding residue
(original residue number in PDB)		H18 T134 L135 G136 H140 D158 C159 M186 D204 S208 Q211 F233 E332
Binding residue
(residue number reindexed from 1)		H18 T81 L82 G83 H87 D105 C106 M133 D151 S155 Q158 F180 E279
Annotation score5
Enzymatic activity
Enzyme Commision number 2.1.1.-
Gene Ontology
Molecular Function
GO:0008168 methyltransferase activity
GO:0071424 rRNA (cytosine-N4-)-methyltransferase activity
Biological Process
GO:0032259 methylation
GO:0070475 rRNA base methylation
Cellular Component
GO:0005739 mitochondrion

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6sgb, PDBe:6sgb, PDBj:6sgb
PDBsum6sgb
PubMed31515389
UniProtQ57W60

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