Structure of PDB 6sg9 Chain F1 Binding Site BS04

Receptor Information
>6sg9 Chain F1 (length=833) Species: 5702 (Trypanosoma brucei brucei) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LEGAMHKPGESGLQAGSSTTIAGKETWSQFSTKMRYGRRRIRVIDVAAKM
SYEYQMLRKMCKRRPAMRQWAVRDDFCDMNPGVVIMSPSMQAAFMKVFRM
KEKGLIRQCLRDIVPVIEYRNREEPARLKRSQAKLRFRIRQRLLKFQRQL
AVANAIASRSVLYSTNDAIGYFLFRGAAMYAGMHRVFFELSKQLPHFVPK
TMLDFGAGTGTAILVAKEVYDPGSLAYPLYRSLRQTMQGNDSSRTHQLSE
LRYDLKRLQRNNEEKKKVRFMAVAALLERGEVDPADLPEDLKREIAEVAT
AAATAKKDRLVREAHARYRDVVDGTEWESGDPLGEVRASTEDPEDVIDGE
QGDGGDDGEAAKGRPKTWWEKLIDVENETARTRAARRLRPLQEVTAVEPS
PGMMEIGTMVLHDDVPNVTWKRYLLPEDEAIQHDLVVAAYSLSEIATSEN
RRRIVQQLWKMTKGVLVFVEFANLNNFNILMEARDWILEEKDVGLWDWQP
TIVAPCPHEHRCPLRHCKTGVKRKRMRICSTEAHYRSTFVEVWARHMPLK
VGIEPISYLILARNELVPERAERRREQLKKAEEMKRRERDVKQQQLHEAS
LAVKDVVFERLSDEALHRVQSSVPQPLTDIDSATSTSLLKDLKDGATSTG
EIGHMPTDVPRLVKTGNTRHNRLIFPLQFPPATHKFNRAFVDAGYQRQRA
ITPAEMLVVRQEVEQLQQRVMRAAPKYLRVVRDPRCHGKVQADFCTPEGD
LVSGRVYRRFYGDRNRVSAHSTMRWQHIGGWKLLKRIRRGSLFPHNVPLY
AVTKHAQIDFPNTLLDTKHSTVEQTAMQYNDPM
Ligand information
Ligand IDSAH
InChIInChI=1S/C14H20N6O5S/c15-6(14(23)24)1-2-26-3-7-9(21)10(22)13(25-7)20-5-19-8-11(16)17-4-18-12(8)20/h4-7,9-10,13,21-22H,1-3,15H2,(H,23,24)(H2,16,17,18)/t6-,7+,9+,10+,13+/m0/s1
InChIKeyZJUKTBDSGOFHSH-WFMPWKQPSA-N
SMILES
SoftwareSMILES
CACTVS 3.341N[CH](CCSC[CH]1O[CH]([CH](O)[CH]1O)n2cnc3c(N)ncnc23)C(O)=O
OpenEye OEToolkits 1.5.0c1nc(c2c(n1)n(cn2)C3C(C(C(O3)CSCCC(C(=O)O)N)O)O)N
CACTVS 3.341N[C@@H](CCSC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n2cnc3c(N)ncnc23)C(O)=O
ACDLabs 10.04O=C(O)C(N)CCSCC3OC(n2cnc1c(ncnc12)N)C(O)C3O
OpenEye OEToolkits 1.5.0c1nc(c2c(n1)n(cn2)[C@H]3[C@@H]([C@@H]([C@H](O3)CSCC[C@@H](C(=O)O)N)O)O)N
FormulaC14 H20 N6 O5 S
NameS-ADENOSYL-L-HOMOCYSTEINE
ChEMBLCHEMBL418052
DrugBankDB01752
ZINCZINC000004228232
PDB chain6sg9 Chain F1B Residue 1 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6sg9 Mitoribosomal small subunit biogenesis in trypanosomes involves an extensive assembly machinery.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		Y256 M264 F290 G291 G293 T294 T296 E483 P484 M488 A524 Y525 E529 E534
Binding residue
(residue number reindexed from 1)		Y171 M179 F205 G206 G208 T209 T211 E398 P399 M403 A439 Y440 E444 E449
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
GO:0008168 methyltransferase activity
GO:0046872 metal ion binding
Biological Process
GO:0006412 translation
Cellular Component
GO:0005739 mitochondrion
GO:0005763 mitochondrial small ribosomal subunit

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6sg9, PDBe:6sg9, PDBj:6sg9
PDBsum6sg9
PubMed31515389
UniProtQ385R2

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