Structure of PDB 8q5u Chain F Binding Site BS04

Receptor Information
>8q5u Chain F (length=769) Species: 1314 (Streptococcus pyogenes) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TDQQVGAKLVQEIREGKRGPLYAGYFRTWHDRASTGIDGKQQHPENTMAE
VPKEVDILFVFHDHTASDSPFWSELKDSYVHKLHQQGTALVQTIGVNELN
GRTGLSKDYPDTPEGNKALAAAIVKAFVTDRGVDGLDIAILHEFTNKRTP
EEDARALNVFKEIAQLIGKNGSDKSKLLIMDTTLSVENNPIFKGIAEDLD
YLLRQYYGSQGGEAEVDTINSDWNQYQNYIDASQFMIGFSFFEESASKGN
LWFEGTRAKKYAEWQPSTGGLKAGIFSYAIDRDGVAHVPSTYKNRTSTQR
HEVDNISHTDYTVSRKLKTLMTEDKRYDVIDQKDIPDPALREQIIQQVGQ
YKGDLERYNKTLVLTGDKIQNLKGLEKLSKLQKLELRQLSNVKEITPELL
PESMKKDAELVMVGMTGLEKLNLSGLNRQTLDGIDVNSITHLTSFDISHN
SLDLSEKSEDRKLLMTLMEQVSNHQKITVKNTAFENQKPKGYYPQTYDTK
EGHYDVDNAEHDILTDFVFGTVTKRNTFIGDEEAFAIYKEGAVDGRQYVS
KDYTYEAFRKDYKGYKVHLTASNLGETVTSKVTATTDETYLVDVSDGEKV
VHHMKLNIGSGAIMMENLAKGAKVIGTSGDFEQAKKIFDGEKSDRFFTWG
QTNWIAFDLGEINLAKEWRLFNAETNTEIKTDSSLNVAKGRLQILKDTTI
DLEKMDIKNRKEYLSNDENWTDVAQMDDAKAIFNSKLSNVLSRYWRFCVD
GGASSYYPQYTELQILGQR
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain8q5u Chain F Residue 903 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8q5u The IgG-specific endoglycosidases EndoS and EndoS2 are distinguished by conformation and antibody recognition.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		K699 D702 E704 T824
Binding residue
(residue number reindexed from 1)		K636 D639 E641 T761
Annotation score1
Gene Ontology
Molecular Function
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0005509 calcium ion binding
GO:0016798 hydrolase activity, acting on glycosyl bonds
GO:0033925 mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity
GO:0046872 metal ion binding
Biological Process
GO:0042783 evasion of host immune response
Cellular Component
GO:0005576 extracellular region
GO:0043655 host extracellular space

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8q5u, PDBe:8q5u, PDBj:8q5u
PDBsum8q5u
PubMed38569940
UniProtT1WGN1|ENDS2_STRP9 Endo-beta-N-acetylglucosaminidase EndoS2 (Gene Name=endoS2)

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