Structure of PDB 8kah Chain F Binding Site BS04 |
| >8kah Chain F (length=1327) Species: 301447 (Streptococcus pyogenes serotype M1)
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KYSIGLAIGTNSVGWAVITDEYKVPSKKFKVLGNTDRHSIKKNLIGALLF
DSGETAEATRLKRTARRRYTRRKNRICYLQEIFSNEMAKVDDSFFHRLEE
SFLVEEDKKHERHPIFGNIVDEVAYHEKYPTIYHLRKKLVDSTDKADLRL
IYLALAHMIKFRGHFLIEGDLNPDNSDVDKLFIQLVQTYNQLFEENPINA
SDAKAILSRRLENLIAQLPGEKKNGLFGNLIALSLGLTPNFKSNFDLAED
ASKDTYDDDLDNLLAQIGDQYADLFLAAKNLSDAILLSDILRVNTEITKA
PLSASMIKRYDEHHQDLTLLKALVRQQLPEKYKEIFFDQSKNGYAGYIDG
GASQEEFYKFIKPILEKMDGTEELLVKLNREDLLRKQRTFDNGSIPHQIH
LGELHAILRRQEDFYPFLKDNREKIEKILTFRIPYYVGPLARGNSRFAWM
TRKSEETITPWNFEEVVDKGASAQSFIERMTNFDKNLPNEKVLPKHSLLY
EYFTVYNELTKVKYVTEGMRKPAFLSGEQKKAIVDLLFKTNRKVTVKQLK
EDYFKKIECFDSVEISGVEDRFNASLGTYHDLLKIIKDKDFLDNEENEDI
LEDIVLTLTLFEDREMIEERLKTYAHLFDDKVMKQLKRRRYTGWGRLSRK
LINGIRDKQSGKTILDFLKSDGFANRNFMQLIHDDSLTFKEDIQKAQVSG
DSLHEHIANLAGSPAIKKGILQTVKVVDELVKVMGRHKPENIVIEMARNS
RERMKRIEEGIKELGSQILKEHPVENTQLQNEKLYLYYLQNGRDMYVDQE
LDINRLSDYDVDAIVPQSFLKDDSIDNKVLTRSDKNRGKSDNVPSEEVVK
KMKNYWRQLLNAKLITQRKFDNLTKAERGGLSELDKAGFIKRQLVETRQI
TKHVAQILDSRMNTKYDENDKLIREVKVITLKSKLVSDFRKDFQFYKVRE
INNYHHAHDAYLNAVVGTALIKKYPKLESEFVYGDYKVYDVRKMIAAKYF
FYSNIMNFFKTEITLANGEIRKRPLIETNGETGEIVWDKGRDFATVRKVL
SMPQVNIVKKTEVQTGGFSKESILPKRNSDKLIARKKDWDPKKYGGFDSP
TVAYSVLVVAKVEKGKSKKLKSVKELLGITIMERSSFEKNPIDFLEAKGY
KEVKKDLIIKLPKYSLFELENGRKRMLASAGELQKGNELALPSKYVNFLY
LASHYEKLKGSPEDNEQKQLFVEQHKHYLDEIIEQISEFSKRVILADANL
DKVLSAYNKHRDKPIREQAENIIHLFTLTNLGAPAAFKYFDTTIDRKRYT
STKEVLDATLIHQSITGLYETRIDLSQ |
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| PDB | 8kah Trans-nuclease activity of Cas9 activated by DNA or RNA target binding. |
| Resolution | 3.36 Å |
Binding residue
(original residue number in PDB) | K30 K31 I43 K44 N46 E57 A59 T62 R69 R70 Y72 R74 R75 S104 T134 I135 H160 K163 Y325 H328 H329 L332 K336 R340 F351 F352 Y359 I363 K401 Q402 R403 L455 A456 R457 N459 S460 T472 I473 P475 K742 K749 P1090 Q1091 E1099 V1100 T1102 G1103 G1104 F1105 R1122 K1123 K1124 F1134 M1169 E1225 L1226 A1227 Q1272 H1349 Q1350 S1351 Y1356 E1357 |
Binding residue
(residue number reindexed from 1) | K27 K28 I40 K41 N43 E54 A56 T59 R66 R67 Y69 R71 R72 S101 T131 I132 H157 K160 Y310 H313 H314 L317 K321 R325 F336 F337 Y344 I348 K386 Q387 R388 L440 A441 R442 N444 S445 T457 I458 P460 K725 K732 P1053 Q1054 E1062 V1063 T1065 G1066 G1067 F1068 R1085 K1086 K1087 F1097 M1132 E1188 L1189 A1190 Q1235 H1312 Q1313 S1314 Y1319 E1320 |
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