Structure of PDB 4iqr Chain F Binding Site BS04

Receptor Information

>4iqr Chain F (length=314) Species: 9606 (Homo sapiens)

ALCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKD
KRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQ
AEVLSRSGINGDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPL
DDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSR
VSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRS
QVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGM
AKIDNLLQEMLLGG

Ligand information

• Ligand ID: ZN
• InChI: InChI=1S/Zn/q+2
• InChIKey: PTFCDOFLOPIGGS-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Zn++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Zn+2]
• Formula: Zn
• Name: ZINC ION
• ChEMBL: CHEMBL1236970
• DrugBank: DB14532
• PDB chain: 4iqr Chain F Residue 402

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4iqr Multidomain integration in the structure of the HNF-4 alpha nuclear receptor complex.
• Resolution: 2.9 Å
• Binding residue (original residue number in PDB): C51 C54 C71
• Binding residue (residue number reindexed from 1): C3 C6 C23
• Annotation score: 4

Gene Ontology

Molecular Function

• GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
• GO:0003677 DNA binding
• GO:0003700 DNA-binding transcription factor activity
• GO:0003707 nuclear steroid receptor activity
• GO:0008270 zinc ion binding
• GO:0043565 sequence-specific DNA binding

Biological Process

• GO:0006355 regulation of DNA-templated transcription

Cellular Component

• GO:0005634 nucleus

External links

• PDB: RCSB:4iqr, PDBe:4iqr, PDBj:4iqr
• PDBsum: 4iqr
• PubMed: 23485969
• UniProt: P41235|HNF4A_HUMAN Hepatocyte nuclear factor 4-alpha (Gene Name=HNF4A)