Structure of PDB 8wwv Chain E Binding Site BS04

Receptor Information

>8wwv Chain E (length=489) Species: 1615674 (Pseudomonas lactis)

DFITKNNLWTNEQRDAADKVLAEIDSLGLEMIRLSWADQYGLLRGKSLTV
ASLKSAFKEGSEVAIGPFFFDLVSSMVFNLFTTAGFEDELSGNPTVVMVP
DPTTFKVLPWADKTGWMLADLHWKSGEPFPLCPRGIMKKAVKSLSDEGYL
FKCGIELEWYLTKIVDRSLSPESLGAPGVQPDAIQVQPVAQGYSVLLEHH
LDQVDDIMSKVRKGLLELNLPLRSIEDEWAPSQMETTFDVMEGLEAADAA
LLIKSAIKQICSRHGYHATFMCKPAINGFFASGWHMHQSLVDKDTRKNLF
IPSEGEVLSPLGRAYAGGLLANGSAASSFTTPTVNGYRRRQPYSLAPDRR
AWAKDNKAAMVRVVSATGDPASRIENRIGEPGANPYLYMASQIVSGLDGI
KNKKDPGELQESPYDAQVPMLPTTLAEALDALEHDSELFRSCFGDTFIKY
WLQLRRSEWARFLDAEGAEAAEPTGAVTQWEQKEYFNLL

Ligand information

• Ligand ID: MN
• InChI: InChI=1S/Mn/q+2
• InChIKey: WAEMQWOKJMHJLA-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mn+2]
  CACTVS 3.341: [Mn++]
• Formula: Mn
• Name: MANGANESE (II) ION
• DrugBank: DB06757
• PDB chain: 8wwv Chain E Residue 504

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8wwv Discovery of the 1-naphthylamine biodegradation pathway reveals a glutamine synthetase-like protein that catalyzes 1-naphthylamine glutamylation
• Resolution: 2.3 Å
• Binding residue (original residue number in PDB): E162 H291 E381
• Binding residue (residue number reindexed from 1): E156 H285 E375
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 6.3.1.2: glutamine synthetase.

Gene Ontology

Molecular Function

• GO:0000166 nucleotide binding
• GO:0003824 catalytic activity
• GO:0004356 glutamine synthetase activity
• GO:0016879 ligase activity, forming carbon-nitrogen bonds
• GO:0046872 metal ion binding

Biological Process

• GO:0006542 glutamine biosynthetic process

Cellular Component

• GO:0005737 cytoplasm
• GO:0016020 membrane

External links

• PDB: RCSB:8wwv, PDBe:8wwv, PDBj:8wwv
• PDBsum: 8wwv
• UniProt: A0A7Y1Q2L1