Structure of PDB 8twa Chain E Binding Site BS04

Receptor Information
>8twa Chain E (length=1123) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AGNKYNTLSNNYALSAQQLLNASKIDDIDSMMGFERYVPPQYNGRFDAKD
IDQIPGRVGWLTNMHATLVSGISGVDFYFLDEEGGSFKSTVVYDPYFFIA
CNDESRVNDVEELVKKYLESCLKSLQIIRKEDLTMDNHLLGLQKTLIKLS
FVNSNQLFEARKLLRPILQDNANNDAKHLIEDIREYDVPYHVRVSIDKDI
RVGKWYKVTQQGFIEDTRKIAFADPVVMAFDIETTKPPLKFPDSAVDQIM
MISYMIDGEGFLITNREIISEDIEDFEYTPKPEYPGFFTIFNENDEVALL
QRFFEHIRDVRPTVISTFNGDFFDWPFIHNRSKIHGLDMFDEIGFAPDAE
GEYKSSYCSHMDCFRWVKRDSYLPQGSQGLKAVTQSKLGYNPIELDPELM
TPYAFEKPQHLSEYSVSDAVATYYLYMKYVHPFIFSLCTIIPLNPDETLR
KGTGTLCEMLLMVQAYQHNILLPNKHTDPIERFYDGHLLESETYVGGHVE
SLEAGVFRSDLKNEFKIDPSAIDELLQELPEALKFSVEVENKSSVDKVTN
FEEIKNQITQKLLELKENNIRNELPLIYHVDVASMYPNIMTTNRLQPDSI
KAERDCASCDFNRPGKTCARKLKWAWRGEFFPSKMDEYNMIKRALQNETF
PNKNKFSKKKVLTFDELSYADQVIHIKKRLTEYSRKVYHRVKVSEIVERE
AIVCQRENPFYVDTVKSFRDRRYEFKGLAKTWKGNLSKIDPSDKHARDEA
KKMIVLYDSLQLAHKVILNSFYGYVMRKGSRWYSMEMAGITCLTGATIIQ
MARALVERVGRPLELDTDGIWCILPKSFPETYFFTLENGKKLYLSYPCSM
LNYRVHQKFTNHQYQELKDPLNYIYETHSENTIFFEVDGPYKAMILPSSK
EEGKGIKKRYAVFNEDGSLAELKGFELKRRGELQLIKNFQSDIFKVFLEG
DTLEGCYSAVASVCNRWLDVLDSHGLMLEDEDLVSLICENRSMSKTLKEY
EGQKSTSITTARRLGDFLKGLQCKYIISSKPFNAPVTERAIPVAIFSADI
PIKRSFLRRWTLDPSLEDLDIRTIIDWGYYRERLGSAIQKIITIPAALQG
VSNPVPRVEHPDWLKRKIATKED
Ligand information
Ligand IDSF4
InChIInChI=1S/4Fe.4S
InChIKeyLJBDFODJNLIPKO-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 2.0.7[S]12[Fe]3[S]4[Fe]1[S]5[Fe]2[S]3[Fe]45
CACTVS 3.385S1[Fe]S[Fe]1.S2[Fe]S[Fe]2
FormulaFe4 S4
NameIRON/SULFUR CLUSTER
ChEMBL
DrugBank
ZINC
PDB chain8twa Chain E Residue 2301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8twa Cryo-EM reveals that Ctf18-RFC collaborates with PolE to load the PCNA clamp onto a leading strand DNA
Resolution4.1 Å
Binding residue
(original residue number in PDB)		C665 C668 F670 N671 C677 A678 C763
Binding residue
(residue number reindexed from 1)		C606 C609 F611 N612 C618 A619 C704
Annotation score1
External links
PDB RCSB:8twa, PDBe:8twa, PDBj:8twa
PDBsum8twa
PubMed
UniProtP21951|DPOE_YEAST DNA polymerase epsilon catalytic subunit A (Gene Name=POL2)

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