Structure of PDB 7rpx Chain E Binding Site BS04

Receptor Information
>7rpx Chain E (length=590) Species: 2287 (Saccharolobus solfataricus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MEFKVIAEYFDKLEKISSRLQLTALLADLLSKSDKTIIDKVVYIIQGKLW
PDFLGYPELGIGEKFLIKAISIATNTDENSVENLYKTIGDLGEVARRLKS
KQQSTGILGFLGTTSKESLTVDEVYSTLSKVALTTGEGSRDLKIRLLAGL
LKKADPLEAKFLVRFVEGRLRVGIGDATVLDAMAIAFGGGQSASEIIERA
YNLRADLGNIAKIIVEKGIEALKTLKPQVGIPIRPMLAERLSNPEEILKK
MGGNAIVDYKYDGERAQIHKKEDKIFIFSRRLENITSQYPDVVDYVSKYI
EGKEFIIEGEIVAIDPESGEMRPFQELMHRKRKSDIYEAIKEYPVNVFLF
DLMYYEDVDYTTKPLEARRKLLESIVKPNDYVKIAHHIQANNVEDLKSFF
YRAISEGGEGVMVKAIGKDAIYQAGARGWLWIKLKRDYQSEMADTVDLVV
VGGFYGKGKRGGKISSLLMAAYNPKTDSFESVCKVASGFSDEQLDELQKK
LMEIKRDVKHPRVNSKMEPDIWVEPVYVAEIIGSEITISPLHTCCQDVVE
KDAGLSIRFPRFIRWRDDKSPEDATTTDEILEMYNKQPKK
Ligand information
Ligand IDMN
InChIInChI=1S/Mn/q+2
InChIKeyWAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mn+2]
CACTVS 3.341[Mn++]
FormulaMn
NameMANGANESE (II) ION
ChEMBL
DrugBankDB06757
ZINC
PDB chain7rpx Chain E Residue 702 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7rpx Cryo-EM structures and biochemical insights into heterotrimeric PCNA regulation of DNA ligase.
Resolution4.2 Å
Binding residue
(original residue number in PDB)		E167 G168
Binding residue
(residue number reindexed from 1)		E167 G168
Annotation score4
Enzymatic activity
Enzyme Commision number 6.5.1.1: DNA ligase (ATP).
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003909 DNA ligase activity
GO:0003910 DNA ligase (ATP) activity
GO:0005524 ATP binding
GO:0016874 ligase activity
GO:0046872 metal ion binding
Biological Process
GO:0006260 DNA replication
GO:0006266 DNA ligation
GO:0006273 lagging strand elongation
GO:0006281 DNA repair
GO:0006310 DNA recombination
GO:0051301 cell division
GO:0071897 DNA biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:7rpx, PDBe:7rpx, PDBj:7rpx
PDBsum7rpx
PubMed34838188
UniProtQ980T8|DNLI_SACS2 DNA ligase (Gene Name=lig)

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