Structure of PDB 7ku7 Chain E Binding Site BS04

Receptor Information
>7ku7 Chain E (length=269) Species: 269446 (Rous sarcoma virus (strain Schmidt-Ruppin A)) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PLREAKDLHTALHIGPRALSKACNISMQQAREVVQTCPHCNSAPALEAGV
NPRGLGPLQIWQTDFTLEPRMAPRSWLAVTVDTASSAIVVTQHGRVTSVA
VQHHWATAIAVLGRPKAIKTDNGSCFTSKSTREWLARWGIAHTTGIPGNS
QGQAMVERANRLLKDKIRVLAEGDGFMKRIPTSKQGELLAKAMYALNHFE
RGENTKTPIQKHWRPTVLTEGPPVKIRIETGEWEKGWNVLVWGRGYAAVK
NRDTDKVIWVPSRKVKPDI
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain7ku7 Chain E Residue 302 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7ku7 Cryo-EM structure of the Rous sarcoma virus octameric cleaved synaptic complex intasome.
Resolution3.4 Å
Binding residue
(original residue number in PDB)		D64 D121
Binding residue
(residue number reindexed from 1)		D64 D121
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.-
2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.1.-.-
3.1.26.4: ribonuclease H.
3.4.23.-
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0008270 zinc ion binding
Biological Process
GO:0015074 DNA integration

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Molecular Function
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Biological Process
External links
PDB RCSB:7ku7, PDBe:7ku7, PDBj:7ku7
PDBsum7ku7
PubMed33712691
UniProtP03354|POL_RSVP Gag-Pol polyprotein (Gene Name=gag-pol)

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