Structure of PDB 6q2j Chain E Binding Site BS04

Receptor Information
>6q2j Chain E (length=571) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LYFSRDAYWEKLYVDQAAGTPLLYVHALRDAPEEVPSFRLGQHLYGTYRT
RLHENNWICIQEDTGLLYLNRSLDHSSWEKLSVRNHGFPLLTVYLKVFLS
PGECQWPGCARVYFSFFNTSFPACSSLKPRELCFPETRPSFRIRENRPPG
TFHQFRLLPVQFLCPNISVAYRLLGLPFRCAPDSLEVSTRWALDREQREK
YELVAVCTVHEVVMVPFPVTVYDEDDSAPTFPAGVDTASAVVEFKRKEDT
VVATLRVFDADVVPASGELVRRYTSTLLPGDTWAQQTFRVEHWPNETSVQ
ANGSFVRATVHDYRLVLNRNLSISENRTMQLAVLVNDSGVLLLHFNVSVL
PVSLHLPSTYSLSVSRRARRFAQIGKVCVENCQAFSGINVQYKLHSSCST
LGVVTSAEDTSGILFVNDTKALRRPKCAELHYMVVATDQQTSRQAQAQLL
VTVEGSYVAEEAGCPLSCAVSKRRLECEECGGLGSPTGRCEWRQGDGKGI
TRNFSTCSPSTKTCPDGHCDVVETQDINICPQDCLRGSIVGGHEPGEPRG
IKAGYGTCNCFPEEEKCFCEP
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain6q2j Chain E Residue 711 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6q2j Cryo-EM analyses reveal the common mechanism and diversification in the activation of RET by different ligands.
Resolution4.1 Å
Binding residue
(original residue number in PDB)		T564 C565 D567 H569 E574 D584
Binding residue
(residue number reindexed from 1)		T513 C514 D516 H518 E523 D533
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Gene Ontology
Molecular Function
GO:0005509 calcium ion binding
Biological Process
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6q2j, PDBe:6q2j, PDBj:6q2j
PDBsum6q2j
PubMed31535977
UniProtP07949|RET_HUMAN Proto-oncogene tyrosine-protein kinase receptor Ret (Gene Name=RET)

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