Structure of PDB 4yb6 Chain E Binding Site BS04

Receptor Information

>4yb6 Chain E (length=293) Species: 195099 (Campylobacter jejuni RM1221)

NTRLRIAIQKSGRLSKESIELLSECGVKMHISLIAFSTNLPIDILRVRDD
DIPGLIFDGVVDLGIIGENVLEENELERQSLGENPSYKLLKKLDFGYCRL
SLALPQENKFQNLKDFEGLRIATSYPQLLKRFMKENGINYKNCTLTGSVE
VAPRANLADAICDLVSSGATLQANNLKEVKVIYESRACLIQKENALSKEK
QALVDKIMLRVAGVMQARESKYIMLHAPKEKLDKIQALLPGVERPTILPL
AHDEKNVALHMVSKENLFWETMEALKEEGASSILVLPIEKMLK

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 4yb6 Chain E Residue 305

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4yb6 Campylobacter jejuni adenosine triphosphate phosphoribosyltransferase is an active hexamer that is allosterically controlled by the twisting of a regulatory tail.
• Resolution: 1.98 Å
• Binding residue (original residue number in PDB): S226 K227
• Binding residue (residue number reindexed from 1): S220 K221
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 2.4.2.17: ATP phosphoribosyltransferase.

Gene Ontology

Molecular Function

• GO:0000287 magnesium ion binding
• GO:0003879 ATP phosphoribosyltransferase activity
• GO:0005524 ATP binding
• GO:0016757 glycosyltransferase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0000105 L-histidine biosynthetic process

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:4yb6, PDBe:4yb6, PDBj:4yb6
• PDBsum: 4yb6
• PubMed: 27191057
• UniProt: Q5HSJ4|HIS1_CAMJR ATP phosphoribosyltransferase (Gene Name=hisG)