Structure of PDB 8ut1 Chain D Binding Site BS04

Receptor Information
>8ut1 Chain D (length=394) Species: 562,9606 [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EFQRKLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLT
TNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADERFD
ATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSY
GGWSLDLQMQEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFT
VTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLT
VFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPD
GGKMPKWTRVILLNWCAWFLRMKPDLAKILEEVRYIANRFRCQDESEAVC
SEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDF
Ligand information
Ligand IDEPJ
InChIInChI=1S/C11H13ClN2/c12-11-4-1-7(6-13-11)9-5-8-2-3-10(9)14-8/h1,4,6,8-10,14H,2-3,5H2/t8-,9+,10+/m0/s1
InChIKeyNLPRAJRHRHZCQQ-IVZWLZJFSA-N
SMILES
SoftwareSMILES
CACTVS 3.341Clc1ccc(cn1)[C@H]2C[C@@H]3CC[C@H]2N3
ACDLabs 10.04Clc1ncc(cc1)C3CC2NC3CC2
OpenEye OEToolkits 1.5.0c1cc(ncc1C2CC3CCC2N3)Cl
CACTVS 3.341Clc1ccc(cn1)[CH]2C[CH]3CC[CH]2N3
OpenEye OEToolkits 1.5.0c1cc(ncc1[C@H]2C[C@@H]3CC[C@H]2N3)Cl
FormulaC11 H13 Cl N2
NameEPIBATIDINE;
(2R)-2-(6-CHLOROPYRIDIN-3-YL)-7-AZABICYCLO[2.2.1]HEPTANE
ChEMBLCHEMBL298826
DrugBankDB07720
ZINCZINC000000402872
PDB chain8ut1 Chain D Residue 607 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8ut1 Alpha7-nicotinic acetylcholine receptor bound to epibatidine
Resolution2.3 Å
Binding residue
(original residue number in PDB)		Y92 W148 Y187 C189 Y194
Binding residue
(residue number reindexed from 1)		Y92 W148 Y187 C189 Y194
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0004888 transmembrane signaling receptor activity
GO:0005216 monoatomic ion channel activity
GO:0005230 extracellular ligand-gated monoatomic ion channel activity
GO:0005506 iron ion binding
GO:0009055 electron transfer activity
GO:0020037 heme binding
GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity
GO:0046872 metal ion binding
Biological Process
GO:0006811 monoatomic ion transport
GO:0022900 electron transport chain
GO:0034220 monoatomic ion transmembrane transport
Cellular Component
GO:0016020 membrane
GO:0042597 periplasmic space
GO:0045211 postsynaptic membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8ut1, PDBe:8ut1, PDBj:8ut1
PDBsum8ut1
PubMed38382524
UniProtP0ABE7|C562_ECOLX Soluble cytochrome b562 (Gene Name=cybC);
P36544|ACHA7_HUMAN Neuronal acetylcholine receptor subunit alpha-7 (Gene Name=CHRNA7)

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