Structure of PDB 7vpz Chain D Binding Site BS04

Receptor Information
>7vpz Chain D (length=1259) Species: 100226 (Streptomyces coelicolor A3(2)) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
FDELRIGLATADDIRQWSHGEVKKPETINYRTLKPEKDGLFCEKIFGPTR
DWECYCGKYKRVRFKGIICERCGVEVTRAKVRRERMGHIELAAPVTHIWY
FKGVPSRLGYLLDLAPKDLEKVIYFAAYMITFVDEERRTRDLPSLEAHVS
VERQQIEQRRDSDLEARAKKLETDLAELEAEGAKADVRRKVREGAEREMK
QLRDRAQREIDRLDEVWNRFKNLKVQDLEGDELLYRELRDRFGTYFDGSM
GAAALQKRLESFDLDEEAERLREIIRTGKGQKKTRALKRLKVVSAFLQTS
NSPKGMVLDCVPVIPPDLRPMVQLDGGRFATSDLNDLYRRVINRNNRLKR
LLDLGAPEIIVNNEKRMLQEAVDALFDNGRRGRPVTGPGNRPLKSLSDML
KGKQGRFRQNLLGKRVDYSARSVIVVGPQLKLHQCGLPKAMALELFKPFV
MKRLVDLNHAQNIKSAKRMVERGRTVVYDVLEEVIAEHPVLLNRAPTLHR
LGIQAFEPQLVEGKAIQIHPLVCTAFNADFDGDQMAVHLPLSAEAQAEAR
ILMLSSNNILKPADGRPVTMPTQDMVLGLFFLTTDSEGRSPKGEGRAFGS
SAEAIMAFDAGDLTLQAKIDIRFPVGTIPPRGFEPPAREEGEPEWQQGDT
FTLKTTLGRALFNELLPEDYPFVDYEVGKKQLSEIVNDLAERYPKVIVAA
TLDNLKAAGFFWATRSGVTVAISDIVVPDAKKEIVKGYEGQDEKVQKQYE
RGLITKEERTQELIAIWTKATNEVAEAMNDNFPKTNPVSMMVNSGARGNM
MQMRQIAGMRGLVSNAKNETIPRPIKASFREGLSVLEYFISTHGARKGLA
DTALRTADSGYLTRRLVDVSQDVIIREEDCGTERGLKLPIATRDADGTLR
KAEDVETSVYARMLAEDVVIDGKVIAPANVDLGDVLIDALVAHGVEEVKT
RSILTCESQVGTCAMCYGRSLATGKLVDIGEAVGIIAAQSIGEPGTQLTM
RTFHTGGVAGDDITQGLPRVVELFEARTPKGVAPISEASGRVRIEETEKT
KKIVVTPDDGSDETAFPISKRARLLVGEGDHVEVGQKLTVGATNPHDVLR
ILGQRAVQVHLVGEVQKVYNSQGVSIHDKHIEIIIRQMLRRVTIIESGDA
ELLPGELVERTKFETENRRVVQEGGHPASGRPQLMGITKASLATESWLSA
ASFQETTRVLTDAAINAKSDSLIGLKENVIIGKLIPAGTGLSRYRNIRVE
PTEEAKAAM
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain7vpz Chain D Residue 1401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7vpz Structural basis of Streptomyces transcription activation by zinc uptake regulator.
Resolution4.14 Å
Binding residue
(original residue number in PDB)		D535 D539
Binding residue
(residue number reindexed from 1)		D529 D533
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0008270 zinc ion binding
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7vpz, PDBe:7vpz, PDBj:7vpz
PDBsum7vpz
PubMed35871291
UniProtQ8CJT1|RPOC_STRCO DNA-directed RNA polymerase subunit beta' (Gene Name=rpoC)

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