Structure of PDB 5m8r Chain D Binding Site BS04

Receptor Information
>5m8r Chain D (length=446) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QFPRQCATVEALRSGMCCPDLSPVSGPGTDRCGSSSGRGRCEAVTADSRP
HSPQYPHDGRDDREVWPLRFFNRTCHCNGNFSGHNCGTCRPGWRGAACDQ
RVLIVRRNLLDLSKEEKNHFVRALDMAKRTTHPLFVIATRRSEEILGPDG
NTPQFENISIYNYFVWTHYYSVKKTFLGVGQESFGEVDFSHEGPAFLTWH
RYHLLRLEKDMQEMLQEPSFSLPYWNFATGKNVCDICTDDLMGSRSNFDS
TLISPNSVFSQWRVVCDSLEDYDTLGTLCNSTEDGPIRRNPAGNVARPMV
QRLPEPQDVAQCLEVGLFDTPPFYSNSTNSFRNTVEGFSDPTGKYDPAVS
SLHNLAHLFLNGTGGQVHLSPNDPIFVLLHTFTDAVFDEWLRRYNADIST
FPLENAPIGHNRQYNMVPFWPPVTNTEMFVTAPDNLGYTYEIQWPS
Ligand information
Ligand IDMMS
InChIInChI=1S/C8H10N2O4/c9-5(8(13)14)3-10-2-1-6(11)7(12)4-10/h1-2,4-5,12H,3,9H2,(H,13,14)/t5-/m0/s1
InChIKeyWZNJWVWKTVETCG-YFKPBYRVSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0C1=CN(C=C(C1=O)O)CC(C(=O)O)N
OpenEye OEToolkits 1.5.0C1=CN(C=C(C1=O)O)C[C@@H](C(=O)O)N
CACTVS 3.341N[CH](CN1C=CC(=O)C(=C1)O)C(O)=O
ACDLabs 10.04O=C(O)C(N)CN1C=CC(=O)C(O)=C1
CACTVS 3.341N[C@@H](CN1C=CC(=O)C(=C1)O)C(O)=O
FormulaC8 H10 N2 O4
NameMIMOSINE;
3-HYDROXY-4-OXO-1(4H)-PYRIDINEALANINE
ChEMBLCHEMBL245416
DrugBankDB01055
ZINCZINC000000902159
PDB chain5m8r Chain D Residue 509 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5m8r Structure of Human Tyrosinase Related Protein 1 Reveals a Binuclear Zinc Active Site Important for Melanogenesis.
Resolution2.4 Å
Binding residue
(original residue number in PDB)		H215 H377 N378 H381 G389 V391 S394
Binding residue
(residue number reindexed from 1)		H191 H353 N354 H357 G365 V367 S370
Annotation score1
Enzymatic activity
Enzyme Commision number 1.14.18.-
Gene Ontology
Molecular Function
GO:0016491 oxidoreductase activity

View graph for
Molecular Function
External links
PDB RCSB:5m8r, PDBe:5m8r, PDBj:5m8r
PDBsum5m8r
PubMed28661582
UniProtP17643|TYRP1_HUMAN 5,6-dihydroxyindole-2-carboxylic acid oxidase (Gene Name=TYRP1)

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