Structure of PDB 5bta Chain D Binding Site BS04
Receptor Information
>5bta Chain D (length=247) Species:
83332
(Mycobacterium tuberculosis H37Rv) [
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NALVRRKSGLPGKLADCRSTDPRKSELYVVEGDSAGGSAKSGRDSMFQAI
LPLRGKIINVEKARIDRVLKNTEVQAIITALGTGIHDEFDIGKLRYHKIV
LMADADVDGQHISTLLLTLLFRFMRPLIENGHVFLAQPPLYKLKWQRSDP
EFAYSDRERDGLLEAGLKAGKKINKEDGIQRYKGLGEMDAKELWETTMDP
SVRVLRQVTLDDAAAADELFSILMGEDVDARRSFITRNAKDVRFLDV
Ligand information
>5bta Chain H (length=21) [
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tcatgaatgactatgcacgta
Receptor-Ligand Complex Structure
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PDB
5bta
Crystal structure and stability of gyrase-fluoroquinolone cleaved complexes from Mycobacterium tuberculosis.
Resolution
2.55 Å
Binding residue
(original residue number in PDB)
E459 D461 G483 K484 D536
Binding residue
(residue number reindexed from 1)
E31 D33 G55 K56 D108
Enzymatic activity
Enzyme Commision number
5.6.2.2
: DNA topoisomerase (ATP-hydrolyzing).
Gene Ontology
Molecular Function
GO:0003677
DNA binding
GO:0003918
DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524
ATP binding
Biological Process
GO:0006265
DNA topological change
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Molecular Function
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Biological Process
External links
PDB
RCSB:5bta
,
PDBe:5bta
,
PDBj:5bta
PDBsum
5bta
PubMed
26792525
UniProt
P9WG45
|GYRB_MYCTU DNA gyrase subunit B (Gene Name=gyrB)
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