Structure of PDB 4fo8 Chain D Binding Site BS04

Receptor Information
>4fo8 Chain D (length=259) Species: 208964 (Pseudomonas aeruginosa PAO1) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TVTIKTPDDIEKMRIAGRLAAEVLEMIGEHIKPGVTTEELDRICHDYIVN
EQKAIPAPLNYKGFPKSICTSINHVVCHGIPNEKPLKEGDILNVDITVIK
DGYHGDTSKMFLVGKTPEWADRLCQITQECMYKGISVVRPGAHLGDIGEI
IQKHAEKNGFSVVREYCGHGIGKVFHEEPQVLHYGRAGTGIELKEGMIFT
IEPMINQGRPETRLLGDGWTAITKDRKLSAQWEHTVLVTADGYEILTLRN
DETFPRTSA
Ligand information
Ligand IDMET
InChIInChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1
InChIKeyFFEARJCKVFRZRR-BYPYZUCNSA-N
SMILES
SoftwareSMILES
CACTVS 3.341CSCC[CH](N)C(O)=O
OpenEye OEToolkits 1.5.0CSCCC(C(=O)O)N
CACTVS 3.341CSCC[C@H](N)C(O)=O
OpenEye OEToolkits 1.5.0CSCC[C@@H](C(=O)O)N
ACDLabs 10.04O=C(O)C(N)CCSC
FormulaC5 H11 N O2 S
NameMETHIONINE
ChEMBLCHEMBL42336
DrugBankDB00134
ZINCZINC000001532529
PDB chain4fo8 Chain D Residue 304 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4fo8 Methionine excision captured by the structures of a methionine aminopeptidase
Resolution1.9 Å
Binding residue
(original residue number in PDB)		F65 D96 D107 H177 E203 E234
Binding residue
(residue number reindexed from 1)		F64 D95 D106 H176 E202 E233
Annotation score4
Enzymatic activity
Catalytic site (original residue number in PDB) D96 D107 H170 H177 E203 E234
Catalytic site (residue number reindexed from 1) D95 D106 H169 H176 E202 E233
Enzyme Commision number 3.4.11.18: methionyl aminopeptidase.
Gene Ontology
Molecular Function
GO:0004177 aminopeptidase activity
GO:0004239 initiator methionyl aminopeptidase activity
GO:0008235 metalloexopeptidase activity
GO:0046872 metal ion binding
GO:0046914 transition metal ion binding
GO:0070006 metalloaminopeptidase activity
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0005829 cytosol

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Cellular Component
External links
PDB RCSB:4fo8, PDBe:4fo8, PDBj:4fo8
PDBsum4fo8
PubMed
UniProtQ9HXY1

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