Structure of PDB 2ch2 Chain D Binding Site BS04

Receptor Information
>2ch2 Chain D (length=387) Species: 7165 (Anopheles gambiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
FTPPPASLRNPLIIPEKIMMGPGPSNCSKRVLTAMTNTVLSNFHAELFRT
MDEVKDGLRYIFQTENRATMCVSGSAHAGMEAMLSNLLEEGDRVLIAVNG
IWAERAVEMSERYGADVRTIEGPPDRPFSLETLARAIELHQPKCLFLTHG
DSSSGLLQPLEGVGQICHQHDCLLIVDAVASLCGVPFYMDKWEIDAVYTG
AQKVLGAPPGITPISISPKALDVIRNRRTKSKVFYWDLLLLGNYWGCYDE
PKRYHHTVASNLIFALREALAQIAEEGLENQIKRRIECAQILYEGLGKMG
LDIFVKDPRHRLPTVTGIMIPKGVDWWKVSQYAMNNFSLEVQGGLGPTFG
KAWRVGIMGECSTVQKIQFYLYGFKESLKATHPDYIF
Ligand information
Ligand IDKY1
InChIInChI=1S/C10H11NO3/c11-8-4-2-1-3-7(8)9(12)5-6-10(13)14/h1-4H,5-6,11H2,(H,13,14)
InChIKeyBIASMBPERGWEBX-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0c1ccc(c(c1)C(=O)CCC(=O)O)N
CACTVS 3.341Nc1ccccc1C(=O)CCC(O)=O
ACDLabs 10.04O=C(c1ccccc1N)CCC(=O)O
FormulaC10 H11 N O3
Name4-(2-AMINOPHENYL)-4-OXOBUTANOIC ACID
ChEMBLCHEMBL1233898
DrugBankDB08060
ZINCZINC000013356580
PDB chain2ch2 Chain D Residue 1392 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2ch2 Crystal Structure of the Anopheles Gambiae 3-Hydroxykynurenine Transaminase
Resolution2.7 Å
Binding residue
(original residue number in PDB)		P24 G25 W104 Q344 R356
Binding residue
(residue number reindexed from 1)		P22 G23 W102 Q342 R354
Annotation score2
Enzymatic activity
Enzyme Commision number 2.6.1.44: alanine--glyoxylate transaminase.
2.6.1.63: kynurenine--glyoxylate transaminase.
Gene Ontology
Molecular Function
GO:0004760 L-serine-pyruvate transaminase activity
GO:0008453 alanine-glyoxylate transaminase activity
GO:0008483 transaminase activity
GO:0016740 transferase activity
GO:0030170 pyridoxal phosphate binding
GO:0047315 kynurenine-glyoxylate transaminase activity
Biological Process
GO:0009436 glyoxylate catabolic process
GO:0019265 glycine biosynthetic process, by transamination of glyoxylate
GO:0097053 L-kynurenine catabolic process
Cellular Component
GO:0005777 peroxisome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2ch2, PDBe:2ch2, PDBj:2ch2
PDBsum2ch2
PubMed16585514
UniProtQ7PRG3|HKT_ANOGA 3-hydroxykynurenine transaminase (Gene Name=HKT)

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