Structure of PDB 1s77 Chain D Binding Site BS04

Receptor Information
>1s77 Chain D (length=828) Species: 10760 (Escherichia phage T7) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SDIELAAIPFNTLADHYGERLAREQLALEHESYEMGEARFRKMFERQLKA
GEVADNAAAKPLITTLLPKMIARINDWFEEVKAKRGKRPTAFQFLQEIKP
EAVAYITIKTTLACLTSADNTTVQAVASAIGRAIEDEARFGRIRDLEAKH
FKKNVEEQLNKRVGHVYKKAFMQVVEADMLSKGAWSSWHKEDSIHVGVRC
IEMLIESTGMVSLHSETIELAPEYAEAIATRAGALAGISPMFQPCVVPPK
PWTGITGGGYWANGRRPLALVRTHSKKALMRYEDVYMPEVYKAINIAQNT
AWKINKKVLAVANVITKWKHCPVEDIPAIEREELPWKRAAAAVYRKDKAR
KSRRISLEFMLEQANKFANHKAIWFPYNMDWRGRVYAVSMFNPQGNDMTK
GLLTLAKGKPIGKEGYYWLKIHGANCAGVDKVPFPERIKFIEENHENIMA
CAKSPLENTWWAEQDSPFCFLAFCFEYAGVQHHGLSYNCSLPLAFDGSCS
GIQHFSAMLRDEVGGRAVNLLPSETVQDIYGIVAKKVNEILQADAINGTD
NEVVKLGTKALAGQWLAYGVTRSVTKRSVMTLAYGSKEFGFRQQVLEDTI
QPAIDSGKGLMFTQPNQAAGYMAKLIWESVSVTVVAAVEAMNWLKSAAKL
LAAEVKDKKTGEILRKRCAVHWVTPDGFPVWQEYKKPIQTRLNLMFLGQF
RLQPTINTNKDSEIDAHKQESGIAPNFVHSQDGSHLRKTVVWAHEKYGIE
SFALIHDSFGTIPADAANLFKAVRETMVDTYESCDVLADFYDQFADQLHE
SQLDKMPALPAKGNLNLRDILESDFAFA
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain1s77 Chain D Residue 903 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1s77 The structural mechanism of translocation and helicase activity in T7 RNA polymerase.
Resolution2.69 Å
Binding residue
(original residue number in PDB)		D537 D812
Binding residue
(residue number reindexed from 1)		D496 D757
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
Biological Process
GO:0006351 DNA-templated transcription
GO:0019083 viral transcription
GO:0039695 DNA-templated viral transcription
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1s77, PDBe:1s77, PDBj:1s77
PDBsum1s77
PubMed15016374
UniProtP00573|RPOL_BPT7 T7 RNA polymerase (Gene Name=1)

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