Structure of PDB 1mow Chain D Binding Site BS04

Receptor Information

>1mow Chain D (length=248) Species: 2275,3055

ENVSGISAYLLGLIWGDGGLYKLKYKGNRSEYRVVITQKSENLIKQFIAP
RMQFLIDELNVKSKIQIVKGDTRYELRVSSKKLYYYFANMLERIRLFNGN
RFLAYLAGIVDGDGSIIAQIKPNQSYKFKHQLSLTFQVTQKTERRWFLDK
LVDEIGVGYVRDRGSVSDYILSEIKPLHNFLTQLQPFLNFKQKQANLVLK
IIEQLPSAKESPDKFLEVCTWVDQIAALNDSKTRKTTSETVRAVLDSL

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 1mow Chain D Residue 374

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1mow Design, Activity and Structure of a Highly Specific Artificial Endonuclease
• Resolution: 2.4 Å
• Binding residue (original residue number in PDB): D521 G616
• Binding residue (residue number reindexed from 1): D17 G112
• Annotation score: 4

Enzymatic activity

• Catalytic site (original residue number in PDB): G616 D617
• Catalytic site (residue number reindexed from 1): G112 D113
• Enzyme Commision number: 3.1.-.-

Gene Ontology

Molecular Function

• GO:0004519 endonuclease activity
• GO:0042802 identical protein binding
• GO:0046872 metal ion binding

Biological Process

• GO:0006314 intron homing

Cellular Component

• GO:0009507 chloroplast

External links

• PDB: RCSB:1mow, PDBe:1mow, PDBj:1mow
• PDBsum: 1mow
• PubMed: 12419232
• UniProt: P05725|DNE1_CHLRE DNA endonuclease I-CreI;
  P21505|DMO1_DESMO Homing endonuclease I-DmoI