Structure of PDB 8iuj Chain C1 Binding Site BS04

Receptor Information

>8iuj Chain C1 (length=495) Species: 3039 (Euglena gracilis)

MINNIMHMINKYTLTTSHKIIGILYGYMGYIAGILGYIISMLIRMELNTQ
GLAIVRKVKEVTIYNNWITIHGLIMLFVFIMPVGIGFYGNYLIPMLIGTS
ELSMPRMNGISFWMLIVGVVIFVISNVLMSKPISSGWTLYPPLSTRDADN
IGVNIDLSLLVVHVLGISSTIGSVNYITTNKYNRHVGLTFMNINIYNFSI
IVTSILLIGSLPILGVAITGLLLDRNINSTIYDVIGDPVLYQHLFWFFGH
PEVYVIILPVFGLTSLILTSIIHKDIFGREGMMYCIISIGVVGYFVWAHH
MFTVGLDIDSRSYFSIATSIISIPTSVKMFSYINTWASGRGFRGNNSSWS
FFSFLICFCFGGFTGLLLSSGSLDIMLHDTYFVVGHFHTVLSLAATFGLL
IAHYFFLPIIFSYSIFESFSFYHTFLLLVGALLVFYPMHLAGLSGMARRV
PEYADIFIPFMTVGFHGTFLLIFSTLTFIRSYFQFLSHINHSNYL

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 8iuj Chain C1 Residue 504

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8iuj Euglena's atypical respiratory chain adapts to the discoidal cristae and flexible metabolism.
• Resolution: 3.06 Å
• Binding residue (original residue number in PDB): H378 D379
• Binding residue (residue number reindexed from 1): H378 D379
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 7.1.1.9: cytochrome-c oxidase.

Gene Ontology

Molecular Function

• GO:0004129 cytochrome-c oxidase activity
• GO:0016491 oxidoreductase activity
• GO:0020037 heme binding
• GO:0046872 metal ion binding

Biological Process

• GO:0006119 oxidative phosphorylation
• GO:0006123 mitochondrial electron transport, cytochrome c to oxygen
• GO:0009060 aerobic respiration
• GO:0015990 electron transport coupled proton transport

Cellular Component

• GO:0005739 mitochondrion
• GO:0005743 mitochondrial inner membrane
• GO:0016020 membrane

External links

• PDB: RCSB:8iuj, PDBe:8iuj, PDBj:8iuj
• PDBsum: 8iuj
• PubMed: 38388527
• UniProt: Q34463