Structure of PDB 8g10 Chain C Binding Site BS04
Receptor Information
>8g10 Chain C (length=346) Species:
10090
(Mus musculus) [
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KLKKVLDKLRLKRKDISEAAETVNKVVERLLRRMQKRESEFKGVEQLNTG
SYYEHVKISAPNQFNVMFKLEVPRIELQEYYETGAFYLVKFPLSHFLEGE
VLSATKMLSKFRKIIKEEVKEIKDIDVSVEKEKPGSPAVTLLIRNPEEIS
VDIILALESKGSWPISTKEGLPIQGWLGTKVRTNLRREPFYLVPKNAQGE
TWRLSFSHTEKYILNNHGIEKTCCESSGAKCCRKECLKLMKYLLEQLKKE
FQELDAFCSYHVKTAIFHMWTQDPQDSQWDPRNLSSCFDKLLAFFLECLR
TEKLDHYFIPKFNLFSQELIDRKSKEFLSKKIEYERNNGFPIFDKL
Ligand information
>8g10 Chain J (length=18) [
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atctgtacatgtacagat
Receptor-Ligand Complex Structure
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PDB
8g10
The structural basis for 2'-5'/3'-5'-cGAMP synthesis by cGAS
Resolution
2.47 Å
Binding residue
(original residue number in PDB)
R161 S165 A168 N196 Y200 K372
Binding residue
(residue number reindexed from 1)
R13 S17 A20 N48 Y52 K211
Enzymatic activity
Enzyme Commision number
2.7.7.86
: cyclic GMP-AMP synthase.
External links
PDB
RCSB:8g10
,
PDBe:8g10
,
PDBj:8g10
PDBsum
8g10
PubMed
38740774
UniProt
Q8C6L5
|CGAS_MOUSE Cyclic GMP-AMP synthase (Gene Name=Cgas)
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