Structure of PDB 7yk1 Chain C Binding Site BS04

Receptor Information
>7yk1 Chain C (length=306) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PNIVLFSGSSHQDLSQRVADRLGLELGKVVTKKFSNQETSVEIGESVRGE
DVYIIQSGCGEINDNLMELLIMINACKIASSSRVTAVIPCFPYARQDKKD
KSRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPAV
LQWIRENIAEWKNCIIVSPDAGGAKRVTSIADRLNVEFALIHKEMVLVGD
VKDRVAILVDDMADTCGTICHAADKLLSAGATKVYAILTHGIFSGPAISR
INNAAFEAVVVTNTIPQEDKMKHCTKIQVIDISMILAEAIRRTHNGESVS
YLFSHV
Ligand information
Ligand IDPO4
InChIInChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-3
InChIKeyNBIIXXVUZAFLBC-UHFFFAOYSA-K
SMILES
SoftwareSMILES
CACTVS 3.341[O-][P]([O-])([O-])=O
ACDLabs 10.04[O-]P([O-])([O-])=O
OpenEye OEToolkits 1.5.0[O-]P(=O)([O-])[O-]
FormulaO4 P
NamePHOSPHATE ION
ChEMBL
DrugBankDB14523
ZINC
PDB chain7yk1 Chain C Residue 403 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7yk1 Structural basis of human PRPS2 filaments.
Resolution3.08 Å
Binding residue
(original residue number in PDB)		D224 C226
Binding residue
(residue number reindexed from 1)		D214 C216
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.6.1: ribose-phosphate diphosphokinase.
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0004749 ribose phosphate diphosphokinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
Biological Process
GO:0006015 5-phosphoribose 1-diphosphate biosynthetic process
GO:0006098 pentose-phosphate shunt
GO:0006139 nucleobase-containing compound metabolic process
GO:0006164 purine nucleotide biosynthetic process
GO:0009156 ribonucleoside monophosphate biosynthetic process
GO:0009165 nucleotide biosynthetic process
GO:0016310 phosphorylation
GO:0044249 cellular biosynthetic process
Cellular Component
GO:0002189 ribose phosphate diphosphokinase complex
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7yk1, PDBe:7yk1, PDBj:7yk1
PDBsum7yk1
PubMed37248548
UniProtP11908|PRPS2_HUMAN Ribose-phosphate pyrophosphokinase 2 (Gene Name=PRPS2)

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