Structure of PDB 7y5n Chain C Binding Site BS04

Receptor Information
>7y5n Chain C (length=1115) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PSRALYFSGRGEQLRLRADLELPRDAFTLQVWLRAEGGQRSPAVITGLYD
KCSYISRDRGWVVGIHTISDQDNKDPRYFFSLKTDRARQVTTINAHRSYL
PGQWVYLAATYDGQFMKLYVNGAQVATSGEQVGGIFSPLTQKCKVLMLGG
SALNHNYRGYIEHFSLWKVARTQREILSDMETHGAHTALPQLLLQENWDN
VKHAWSPMKDGSSPKVEFSNAHGFLLDTSLEPPLCGQTLCDNTEVIASYN
QLSSFRQPKVVRYRVVNLYEDDHKNPTVTREQVDFQHHQLAEAFKQYNIS
WELDVLEVSNSSLRRRLILANCDISKIGDENCDPECNHTLTGHDGGDCRH
LRHPAFVKKQHNGVCDMDCNYERFNFDGGECCDPEITNVTQTCFDPDSPH
RAYLDVNELKNILKLDGSTHLNIFFAKSSEEELAGVATWPWDKEALMHLG
GIVLNPSFYGMPGHTHTMIHEIGHSLGLYHVFRGISEIQSCSDPCMETEP
SFETGDLCNDTNPAPKHKSCGDPGPGNDTCGFHSFFNTPYNNFMSYADDD
CTDSFTPNQVARMHCYLDLVYQGWQPSRKPAPVALAPQVLGHTTDSVTLE
WFPPIDGHFFERELGSACHLCLEGRILVQYASNASSPMPCSPSGHWSPRE
AEGHPDVEQPCKSSVRTWSPNSAVNPHTVPPACPEPQGCYLELEFLYPLV
PESLTIWVTFVSTDWDSSGAVNDIKLLAVSGKNISLGPQNVFCDVPLTIR
LWDVGEEVYGIQIYTLDEHLEIDAAMLTSTADTPLCLQCKPLKYKVVRDP
PLQMDVASILHLNRKFVDMDLNLGSVYQYWVITISGTEESEPSPAVTYIH
GSGYCGDGIIQKDQGEQCDDMNKINGDGCSLFCRQEVSFNCIDEPSRCYF
HDGDGVCEEFEQKTSIKDCGVYTPQGFLDQWASNASVSHQDQQCPGWVII
GQPAASQVCRTKVIDLSEGISQHAWYPCTISYPYSQLAQTTFWLRAYFSQ
PMVAAAVIVHLVTDGTYYGDQKQETISVQLLDTKDQSHDLGLHVLSCRNN
PLIIPVVHDLSQPFYHSQAVRVSFSSPLVAISGVALRSFDNFDPVTLSSC
QRGETYSPAEQSCVH
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain7y5n Chain C Residue 1613 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7y5n Structural insights into the covalent regulation of PAPP-A activity by proMBP and STC2.
Resolution3.45 Å
Binding residue
(original residue number in PDB)		Y866 D869 I871 Q873 E878 D881
Binding residue
(residue number reindexed from 1)		Y854 D857 I859 Q861 E866 D869
Annotation score4
Enzymatic activity
Enzyme Commision number 3.4.24.79: pappalysin-1.
Gene Ontology
Molecular Function
GO:0004175 endopeptidase activity
GO:0004222 metalloendopeptidase activity
GO:0005515 protein binding
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006508 proteolysis
GO:0007166 cell surface receptor signaling pathway
GO:0007565 female pregnancy
GO:0030163 protein catabolic process
GO:0032354 response to follicle-stimulating hormone
GO:0071548 response to dexamethasone
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7y5n, PDBe:7y5n, PDBj:7y5n
PDBsum7y5n
PubMed36550107
UniProtQ13219|PAPP1_HUMAN Pappalysin-1 (Gene Name=PAPPA)

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