Structure of PDB 7dxg Chain C Binding Site BS04

Receptor Information
>7dxg Chain C (length=698) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LSIEEERFLDAAEYGNIPVVRKMLEECHSLNVNCVDYMGQNALQLAVANE
HLEITELLLKKENLSRVGDALLLAISKGYVRIVEAILSHPAFAEGKRLDD
FYAYDEDGTRFSHDVTPIILAAHCQEYEIVHTLLRKGARIERPHDYFCKC
NDCNQKQKHDSFSHSRSRINAYKGLASPAYLSLSSEDPVMTALELSNELA
VLANIEKEFKNDYKKLSMQCKDFVVGLLDLCRNTEEVEAILNGDVETLQS
GDHGRPNLSRLKLAIKYEVKKFVAHPNCQQQLLSIWYENLSGLRQQTMAV
KFLVVLAVAIGLPFLALIYWFAPCSKMGKIMRGPFMKFVAHAASFTIFLG
LLVMNAADRFEGTLFRMKTSCFSWMEMLIISWVIGMIWAECKEIWTQGPK
EYLFELWNMLDFGMLAIFAASFIARFMAFWHASKAQSIIDNVKYYNLARI
KWDPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDI
FKFMVIFIMVFVAFMIGMFNLYSYYIGAKQNEAFTTVEESFKTLFWAIFG
LSEVKSVVINYNHKFIENIGYVLYGVYNVTMVIVLLNMLIAMINSSFQDA
DVEWKFARAKLWFSYFEEGRTLPVPFNLVPRQYQKIMKRLIKRYVLQAQI
DKESDEVNEGELKEIKQDISSLRYELLEEKSQNTEDLAELIRELGEKL
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7dxg Chain C Residue 1002 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7dxg Structural mechanism of human TRPC3 and TRPC6 channel regulation by their intracellular calcium-binding sites.
Resolution2.9 Å
Binding residue
(original residue number in PDB)		H249 C258
Binding residue
(residue number reindexed from 1)		H144 C153
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
GO:0005261 monoatomic cation channel activity
GO:0005262 calcium channel activity
GO:0005515 protein binding
GO:0015279 store-operated calcium channel activity
GO:0042803 protein homodimerization activity
GO:0070679 inositol 1,4,5 trisphosphate binding
Biological Process
GO:0006811 monoatomic ion transport
GO:0006812 monoatomic cation transport
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007338 single fertilization
GO:0032414 positive regulation of ion transmembrane transporter activity
GO:0051480 regulation of cytosolic calcium ion concentration
GO:0051928 positive regulation of calcium ion transport
GO:0055085 transmembrane transport
GO:0070588 calcium ion transmembrane transport
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0034703 cation channel complex
GO:0036057 slit diaphragm

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7dxg, PDBe:7dxg, PDBj:7dxg
PDBsum7dxg
PubMed35051376
UniProtQ9Y210|TRPC6_HUMAN Short transient receptor potential channel 6 (Gene Name=TRPC6)

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