Structure of PDB 6vzu Chain C Binding Site BS04

Receptor Information
>6vzu Chain C (length=396) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KRLVINLSNCRYDSVRRAAQQYGLREAGDNDDWTLYWTDYSVSLERVMEM
KSYQKINHFPGMSEICRKDLLARNMSRMLKLFPKDFHFFPRTWCLPADWG
DLQTYSRTRKNKTYICKPDSGCQGRGIFITRSVKEIKPGEDMICQLYISK
PFIIDGFKFDLRVYVLVTSCDPLRVFVYNEGLARFATTSYSHPNLDNLDE
ICMHLTNYSINKHSSNFVQDAFSGSKRKLSTFNSYMKTHGYDVEQIWRGI
EDVIIKTLISAHPVIKHNYHTCFPSHTLNSACFEILGFDILLDRKLKPWL
LEVNHSPSFSTDSKLDKEVKDSLLYDALVLINLGNCDKKKVLEEERQRGR
EIRLEEVKGFQAMRLQKTEEYEKKNCGGFRLIYPGLNLEKYDKFFQ
Ligand information
Ligand IDRZP
InChIInChI=1S/C12H21NO12P2/c1-7(14)13-9(3-5-11(17)18)26(21,25-27(22,23)24)6-8(12(19)20)2-4-10(15)16/h8-9H,2-6H2,1H3,(H,13,14)(H,15,16)(H,17,18)(H,19,20)(H2,22,23,24)/t8-,9-,26-/m1/s1
InChIKeyUGEFVXZLVYNKBK-IFMBPYNJSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 2.0.7CC(=O)NC(CCC(=O)O)P(=O)(CC(CCC(=O)O)C(=O)O)OP(=O)(O)O
CACTVS 3.385CC(=O)N[C@@H](CCC(O)=O)[P@@](=O)(C[C@@H](CCC(O)=O)C(O)=O)O[P](O)(O)=O
CACTVS 3.385CC(=O)N[CH](CCC(O)=O)[P](=O)(C[CH](CCC(O)=O)C(O)=O)O[P](O)(O)=O
OpenEye OEToolkits 2.0.7CC(=O)N[C@@H](CCC(=O)O)[P@@](=O)(C[C@@H](CCC(=O)O)C(=O)O)OP(=O)(O)O
FormulaC12 H21 N O12 P2
Name(2~{S})-2-[[[(1~{R})-1-acetamido-4-oxidanyl-4-oxidanylidene-butyl]-phosphonooxy-phosphoryl]methyl]pentanedioic acid
ChEMBL
DrugBank
ZINC
PDB chain6vzu Chain C Residue 705 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6vzu Structural basis for polyglutamate chain initiation and elongation by TTLL family enzymes.
Resolution1.98 Å
Binding residue
(original residue number in PDB)		C179 Q180 R219 L239 R241 N264 Y265 S266 K283 E359 N361 S363 P364 S365 K377
Binding residue
(residue number reindexed from 1)		C122 Q123 R162 L182 R184 N207 Y208 S209 K226 E302 N304 S306 P307 S308 K320
Annotation score1
Enzymatic activity
Enzyme Commision number 6.3.2.-
Gene Ontology
Biological Process
GO:0036211 protein modification process

View graph for
Biological Process
External links
PDB RCSB:6vzu, PDBe:6vzu, PDBj:6vzu
PDBsum6vzu
PubMed32747782
UniProtA4Q9E8|TTLL6_MOUSE Tubulin polyglutamylase TTLL6 (Gene Name=Ttll6)

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