Structure of PDB 6gys Chain C Binding Site BS04

Receptor Information
>6gys Chain C (length=573) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TQLKSKHPCSVCTRRKVKCDRMIPCGNCRKRGQDSECMKSTITASSSKEY
LPDLLLFWQNYEYWITNIGLYKTKQRDLTRTPANLDTDTEECMFWMNYLQ
KDQSFQLMNFAMENLGALYFGSIGDISELYLRVEQYWDRRADKNHSVDGK
YWDALIWSVFTMCIYYMPVEKLAEIFSVYPLHEYLGSNKRLNWEDGMQLV
MCQNFARCSLFQLKQCDFMAHPDIRLVQAYLILATTTFPYDEPLLANSLL
TQCIHTFKNFHVDDFRPLLNDDPVESIAKVTLGRIFYRLCGCDYLQSGPR
KPIALHTEVSSLLQHAAYLQDNSTEVLYWKIISLDRDLDQYLNKSSKPPL
KTLDAIRRELDIFQYKVDSLEEDFRSNNSRFQKFIALFQISTVSWKLFKM
YLIYYDTADSLLKVIHYSKVIISLIVNNFHAKSEFFNRHPMVMQTITRVV
SFISFYQIFVESAAVKQLLVDLTELTANLPTIFGSKLDKLVYLTERLSKL
KLLWDKVQLLDSGDSFYHPVFKILQNDIKIIELKNDEMFSLIKGLGSLVP
LNSDFRTIVEEFQSEYNISDILS
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain6gys Chain C Residue 702 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6gys Architecture of the CBF3-centromere complex of the budding yeast kinetochore.
Resolution4.4 Å
Binding residue
(original residue number in PDB)		C30 C33
Binding residue
(residue number reindexed from 1)		C25 C28
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0008301 DNA binding, bending
GO:0019237 centromeric DNA binding
GO:0042802 identical protein binding
GO:0046872 metal ion binding
Biological Process
GO:0000921 septin ring assembly
GO:0006355 regulation of DNA-templated transcription
GO:0006357 regulation of transcription by RNA polymerase II
GO:0007094 mitotic spindle assembly checkpoint signaling
GO:0051382 kinetochore assembly
Cellular Component
GO:0000775 chromosome, centromeric region
GO:0000776 kinetochore
GO:0005634 nucleus
GO:0005694 chromosome
GO:0031518 CBF3 complex

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6gys, PDBe:6gys, PDBj:6gys
PDBsum6gys
PubMed30478265
UniProtP40969|CBF3B_YEAST Centromere DNA-binding protein complex CBF3 subunit B (Gene Name=CEP3)

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