Structure of PDB 6f1h Chain C Binding Site BS04

Receptor Information
>6f1h Chain C (length=286) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IPQKLFEVTSPLFPKPYPNNFETTTVITVPTGYRVKLVFQQFDLEPSEGC
FYDYVKISADKKSLGRFCGQLGSPLGNPPGKKEFMSQGNKMLLTFHTDFS
NEENGTIMFYKGFLAYYQAVDLDECASRSKSGEEDPQPQCQHLCHNYVGG
YFCSCRPGYELQEDTHSCQAECSSELYTEASGYISSLEYPRSYPPDLRCN
YSIRVERGLTLHLKFLEPFDIDDHQQVHCPYDQLQIYANGKNIGEFCGKQ
RPPDLDTSSNAVDLLFFTDESGDSRGWKLRYTTEII
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain6f1h Chain C Residue 304 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6f1h Structure of the C1r-C1s interaction of the C1 complex of complement activation.
Resolution4.5 Å
Binding residue
(original residue number in PDB)		Y197 D226 D236 D273 S275
Binding residue
(residue number reindexed from 1)		Y193 D222 D232 D269 S271
Annotation score4
Enzymatic activity
Enzyme Commision number 3.4.21.41: complement subcomponent C1r.
Gene Ontology
Molecular Function
GO:0005509 calcium ion binding

View graph for
Molecular Function
External links
PDB RCSB:6f1h, PDBe:6f1h, PDBj:6f1h
PDBsum6f1h
PubMed29311313
UniProtP00736|C1R_HUMAN Complement C1r subcomponent (Gene Name=C1R)

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