Structure of PDB 5yew Chain C Binding Site BS04

Receptor Information

>5yew Chain C (length=389) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

SPLKHFVLAKKAITAIFDQLLEFVTEGSHFVEATYKNPELDRIATEDDLV
EMQGYKDKLSIIGEVLSRRHMKVAFFGRTSSGKSSVINAMLWDKVLPSGI
GHITNCFLSVEGTDGDKAYLMTEGSDEKKSVKTVNQLAHALHMDKDLKAG
CLVRVFWPKAKCALLRDDLVLVDSPGTDVTTELDSWIDKFCLDADVFVLV
ANSESTLMNTEKHFFHKVNERLSKPNIFILNNRWDASASEPEYMEDVRRQ
HMERCLHFLVEELKVVNALEAQNRIFFVSAKEVLSARKQKALAEGFHARL
QEFQNFEQIFEECISQSAVKTKFEQHTIRAKQILATVKNIMDSVNLAAED
LPKEIDQLEKIQNNSKLLRNKAVQLENELENFTKQFLPS

Ligand information

Ligand ID

InChI

InChI=1S/Mg/q+2

InChIKey

JLVVSXFLKOJNIY-UHFFFAOYSA-N

SMILES

Software	SMILES
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Mg+2]
CACTVS 3.341	[Mg++]

Formula

Name

MAGNESIUM ION

PDB chain

5yew Chain C Residue 804 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	5yew Structural basis for GTP hydrolysis and conformational change of MFN1 in mediating membrane fusion
Resolution	3.2 Å
Binding residue (original residue number in PDB)	S89 T109
Binding residue (residue number reindexed from 1)	S84 T104
Annotation score	1

Enzymatic activity

Enzyme Commision number

3.6.5.-

Gene Ontology

	Molecular Function
GO:0003924	GTPase activity
GO:0005525	GTP binding

	Biological Process
GO:0008053	mitochondrial fusion

	Cellular Component
GO:0005741	mitochondrial outer membrane
GO:0016020	membrane

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:5yew, PDBe:5yew, PDBj:5yew
PDBsum	5yew
PubMed	29483649
UniProt	Q8IWA4\|MFN1_HUMAN Mitofusin-1 (Gene Name=MFN1)

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