Structure of PDB 5bti Chain C Binding Site BS04

Receptor Information
>5bti Chain C (length=487) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IEPVDIEQEMQRSYIDYAMSVIVGRALPEVRDGLKPVHRRVLYAMFDSGF
RPDRSHAKSARSVAETMGNYHPHGDSSIYDSLVRMAQPWSLRYPLVDGQG
NFGSPGNDPPAAMRYTEARLTPLAMEMLREIDEETVDFIPNYDGRVQEPT
VLPSRFPNLLANGSGGIAVGMATNIPPHNLRELADAVFWALENHDADEEE
TLAAVMGRVKGPDFPTAGLIVGSQGTADAYKTGRGSIRMRGVVEVEEDSR
GRTSLVITELPYQVNHDNFITSIAEQVRDGKLAGISNIEDQSSDRVGLRI
VIEIKRDAVAKVVINNLYKHTQLQTSFGANMLAIVDGVPRTLRLDQLIRY
YVDHQLDVIVRRTTYRLRKANERAHILRGLVKALDALDEVIALIRASETV
DIARAGLIELLDIDEIQAQAILDMQLRRLAALERQRIIDDLAKIEAEIAD
LEDILAKPERQRGIVRDELAEIVDRHGDDRRTRIIAI
Ligand information
Receptor-Ligand Complex Structure
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PDB5bti Crystal structure and stability of gyrase-fluoroquinolone cleaved complexes from Mycobacterium tuberculosis.
Resolution2.501 Å
Binding residue
(original residue number in PDB)		R39 H52 H85 H87 S95 R98 I181
Binding residue
(residue number reindexed from 1)		R25 H38 H71 H73 S81 R84 I167
Enzymatic activity
Enzyme Commision number 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524 ATP binding
Biological Process
GO:0006259 DNA metabolic process
GO:0006265 DNA topological change

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Molecular Function
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Biological Process
External links
PDB RCSB:5bti, PDBe:5bti, PDBj:5bti
PDBsum5bti
PubMed26792525
UniProtP9WG47|GYRA_MYCTU DNA gyrase subunit A (Gene Name=gyrA)

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