Structure of PDB 4gx1 Chain C Binding Site BS04

Receptor Information
>4gx1 Chain C (length=546) Species: 243231 (Geobacter sulfurreducens PCA) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NLKVLLLYCAFLLVMLLAYASIFRYLMWHLEGRAYSFMAGIYWTITVMTT
LGFGDITFESDAGYLFASIVTVSGVIFLDIILPFGFVSMFLAPWIERRLR
YHPTIELPDDTRGHILIFGIDPITRTLIRKLESRNHLFVVVTDNYDQALH
LEEQEGFKVVYGSPTDAHVLAGLRVAAARSIIANLSDPDNANLCLTVRSL
CQTPIIAVVKEPVHGELLRLAGANQVVPLTRILGRYLGIRATTCGALAHI
LDSFGNLQIAELPVHGTPFAGKTIGESGIRQRTGLSIIGVWERGSLTTPQ
RETVLTEQSLLVLAGTKSQLAALEYLIGEAPEDELIFIIGHGRIGCAAAA
FLDRKPVPFILIDRQESPVCNDHVVVYGDATVGQTLRQAGIDRASGIIVT
TNDDSTNIFLTLACRHLHSHIRIVARANGEENVDQLYAAGADFVVSNASV
GANILGNLLEHKESAFLSEGMAVFRRPLPPAMAGKTIAETRLRPLTGCSI
VAIEAPDRADILISPPPETILAEGARLILIGTSEQEKTFDQTIAAR
Ligand information
Ligand IDADP
InChIInChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1
InChIKeyXTWYTFMLZFPYCI-KQYNXXCUSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0c1nc(c2c(n1)n(cn2)[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@](=O)(O)OP(=O)(O)O)O)O)N
CACTVS 3.341Nc1ncnc2n(cnc12)[CH]3O[CH](CO[P](O)(=O)O[P](O)(O)=O)[CH](O)[CH]3O
ACDLabs 10.04O=P(O)(O)OP(=O)(O)OCC3OC(n2cnc1c(ncnc12)N)C(O)C3O
CACTVS 3.341Nc1ncnc2n(cnc12)[C@@H]3O[C@H](CO[P@@](O)(=O)O[P](O)(O)=O)[C@@H](O)[C@H]3O
OpenEye OEToolkits 1.5.0c1nc(c2c(n1)n(cn2)C3C(C(C(O3)COP(=O)(O)OP(=O)(O)O)O)O)N
FormulaC10 H15 N5 O10 P2
NameADENOSINE-5'-DIPHOSPHATE
ChEMBLCHEMBL14830
DrugBankDB16833
ZINCZINC000012360703
PDB chain4gx1 Chain C Residue 607 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4gx1 Distinct gating mechanisms revealed by the structures of a multi-ligand gated K(+) channel.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		G360 R361 D381 R382 G396 D397 A398 T419 N420 R444
Binding residue
(residue number reindexed from 1)		G342 R343 D363 R364 G378 D379 A380 T401 N402 R426
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003674 molecular_function
GO:0008324 monoatomic cation transmembrane transporter activity
GO:0046872 metal ion binding
Biological Process
GO:0006813 potassium ion transport
GO:0008150 biological_process
GO:0098655 monoatomic cation transmembrane transport
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4gx1, PDBe:4gx1, PDBj:4gx1
PDBsum4gx1
PubMed23240087
UniProtQ74FS9

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