Structure of PDB 3bcc Chain C Binding Site BS04

Receptor Information
>3bcc Chain C (length=379) Species: 9031 (Gallus gallus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
APNIRKSHPLLKMINNSLIDLPAPSNISAWWNFGSLLAVCLMTQILTGLL
LAMHYTADTSLAFSSVAHTCRNVQYGWLIRNLHANGASFFFICIFLHIGR
GLYYGSYLYKETWNTGVILLLTLMATAFVGYVLPWGQMSFWGATVITNLF
SAIPYIGHTLVEWAWGGFSVDNPTLTRFFALHFLLPFAIAGITIIHLTFL
HESGSNNPLGISSDSDKIPFHPYYSFKDILGLTLMLTPFLTLALFSPNLL
GDPENFTPANPLVTPPHIKPEWYFLFAYAILRSIPNKLGGVLALAASVLI
LFLIPFLHKSKQRTMTFRPLSQTLFWLLVANLLILTWIGSQPVEHPFIII
GQMASLSYFTILLILFPTIGTLENKMLNY
Ligand information
Ligand IDAMY
InChIInChI=1S/C27H38N2O9/c1-6-7-8-10-19-24(38-21(31)13-15(2)3)17(5)37-27(35)22(16(4)36-26(19)34)29-25(33)18-11-9-12-20(23(18)32)28-14-30/h9,11-12,14-17,19,22,24,32H,6-8,10,13H2,1-5H3,(H,28,30)(H,29,33)/t16-,17+,19+,22-,24-/m0/s1
InChIKeyZVYMCLIDNNTNCL-BJDKEMKCSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0CCCCC[C@@H]1[C@H]([C@H](OC(=O)[C@H]([C@@H](OC1=O)C)NC(=O)c2cccc(c2O)NC=O)C)OC(=O)CC(C)C
OpenEye OEToolkits 1.5.0CCCCCC1C(C(OC(=O)C(C(OC1=O)C)NC(=O)c2cccc(c2O)NC=O)C)OC(=O)CC(C)C
CACTVS 3.341CCCCC[CH]1[CH](OC(=O)CC(C)C)[CH](C)OC(=O)[CH](NC(=O)c2cccc(NC=O)c2O)[CH](C)OC1=O
CACTVS 3.341CCCCC[C@@H]1[C@@H](OC(=O)CC(C)C)[C@@H](C)OC(=O)[C@@H](NC(=O)c2cccc(NC=O)c2O)[C@H](C)OC1=O
ACDLabs 10.04O=CNc1cccc(c1O)C(=O)NC2C(=O)OC(C(OC(=O)CC(C)C)C(C(=O)OC2C)CCCCC)C
FormulaC27 H38 N2 O9
NameANTIMYCIN
ChEMBL
DrugBank
ZINCZINC000058638487
PDB chain3bcc Chain C Residue 384 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB3bcc Electron transfer by domain movement in cytochrome bc1.
Resolution3.7 Å
Binding residue
(original residue number in PDB)		W32 N33 G35 S36 L42 M43 A191 L198 F221 D229
Binding residue
(residue number reindexed from 1)		W31 N32 G34 S35 L41 M42 A190 L197 F220 D228
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) H202 S206 K228 D229 E272
Catalytic site (residue number reindexed from 1) H201 S205 K227 D228 E271
Enzyme Commision number 1.10.2.2: Transferred entry: 7.1.1.8.
Gene Ontology
Molecular Function
GO:0008121 ubiquinol-cytochrome-c reductase activity
GO:0009055 electron transfer activity
GO:0016491 oxidoreductase activity
GO:0020037 heme binding
GO:0046872 metal ion binding
Biological Process
GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c
GO:0006979 response to oxidative stress
GO:0022904 respiratory electron transport chain
GO:1902600 proton transmembrane transport
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0016020 membrane
GO:0045275 respiratory chain complex III

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3bcc, PDBe:3bcc, PDBj:3bcc
PDBsum3bcc
PubMed9565029
UniProtP18946|CYB_CHICK Cytochrome b (Gene Name=MT-CYB)

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