Structure of PDB 1anx Chain C Binding Site BS04
Receptor Information
>1anx Chain C (length=316) Species:
9606
(Homo sapiens) [
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QVLRGTVTDFPGFDERADAETLRKAMKGLGTDEESILTLLTSRSNAQRQE
ISAAFKTLFGRDLLDDLKSELTGKFEKLIVALMKPSRLYDAYELKHALKG
AGTNEKVLTEIIASRTPEELRAIKQVYEEEYGSSLEDDVVGDTSGYYQRM
LVVLLQANRDPDAGIDEAQVEQDAQALFQAGELKWGTDEEKFITIFGTRS
VSHLRKVFDKYMTISGFQIEETIDRETSGNLEQLLLAVVKSIRSIPAYLA
ETLYYAMKGAGTDDHTLIRVMVSRSEIDLFNIRKEFRKNFATSLYSMIKG
DTSGDYKKALLLLCGE
Ligand information
Ligand ID
CA
InChI
InChI=1S/Ca/q+2
InChIKey
BHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
Software
SMILES
CACTVS 3.341
[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0
[Ca+2]
Formula
Ca
Name
CALCIUM ION
ChEMBL
DrugBank
DB14577
ZINC
PDB chain
1anx Chain C Residue 325 [
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Receptor-Ligand Complex Structure
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PDB
1anx
The crystal structure of a new high-calcium form of annexin V.
Resolution
1.9 Å
Binding residue
(original residue number in PDB)
D226 T229 E234
Binding residue
(residue number reindexed from 1)
D224 T227 E232
Annotation score
4
Enzymatic activity
Enzyme Commision number
?
Gene Ontology
Molecular Function
GO:0001786
phosphatidylserine binding
GO:0004859
phospholipase inhibitor activity
GO:0005509
calcium ion binding
GO:0005515
protein binding
GO:0005543
phospholipid binding
GO:0005544
calcium-dependent phospholipid binding
Biological Process
GO:0007165
signal transduction
GO:0007596
blood coagulation
GO:0043066
negative regulation of apoptotic process
GO:0050819
negative regulation of coagulation
Cellular Component
GO:0005576
extracellular region
GO:0005737
cytoplasm
GO:0005829
cytosol
GO:0005925
focal adhesion
GO:0009897
external side of plasma membrane
GO:0012506
vesicle membrane
GO:0016020
membrane
GO:0042383
sarcolemma
GO:0062023
collagen-containing extracellular matrix
GO:0070062
extracellular exosome
GO:0072563
endothelial microparticle
View graph for
Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB
RCSB:1anx
,
PDBe:1anx
,
PDBj:1anx
PDBsum
1anx
PubMed
8254674
UniProt
P08758
|ANXA5_HUMAN Annexin A5 (Gene Name=ANXA5)
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