Structure of PDB 8ove Chain Bf Binding Site BS04

Receptor Information
>8ove Chain Bf (length=400) Species: 5702 (Trypanosoma brucei brucei) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SHCKFEHPRHGHLGFLPRKRSRQIRGRARSFPKDDPSQKPHLTSFMVYKA
GMTHIVRDVDRPGSKVNKKEVVEPVTILEAPPMVVVGIVGYRQTPVGHKT
IGTVWAHHTSVEFRRRFYKNWKQSAQLAFTKRKQFARTTEGRLAEARTLK
AFEKKADIIRVVAHTQLRKLRNNRVGVKKAHVSEIQINGGTIAQKIELAK
SLLEKEVRIDSVFQQSEACDVCAVTKGHGFTGVVKRWGVACLPRKTHRGL
RKVACIGAWHPSRVMYTVARAGQHGYHHRTHLNKKIYQLGRAVSMEPNQA
TTAYDLTAKTITPMGGFVGYGTVRNDYVMLKGSVAGPRRRVITLRRPMAP
QTSRKLTEKITLKFIDTSSKIGHGRFQTKKEKSQWYGPLKKDRIRREERL
Ligand information
>8ove Chain BH (length=118) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ugucccucuccaaacgagaguacaugcaugggcuggcaugagcggcacgc
uccauggggcucgaggggcaccgucccgaggcgcugaaccuugaugcuug
gaaucaugcucagggacu
.<<<<<.<<<.......>>>.....<<<<<<<<.<<.....<<<....<.
<<<...>>>.>....<<<......>>>....>>>....>>.....>>>..
....>>>>>...>>>>>.
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8ove A single pseudouridine on rRNA regulates ribosome structure and function in the mammalian parasite Trypanosoma brucei.
Resolution2.6 Å
Binding residue
(original residue number in PDB)		R21 I25 R117 K120 N121 K123 Q124 N174 R175 G177 V178 K179 K180 K227 G228 G230 F231 Y277 M315 G316 G320 R325 R340 R341 S370 I372 K380 K383 W386 Y387 K391
Binding residue
(residue number reindexed from 1)		R20 I24 R116 K119 N120 K122 Q123 N173 R174 G176 V177 K178 K179 K226 G227 G229 F230 Y276 M314 G315 G319 R324 R339 R340 S369 I371 K379 K382 W385 Y386 K390
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
Cellular Component
GO:0005762 mitochondrial large ribosomal subunit
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8ove, PDBe:8ove, PDBj:8ove
PDBsum8ove
PubMed37985661
UniProtQ581Q1

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