Structure of PDB 8xa9 Chain B Binding Site BS04

Receptor Information
>8xa9 Chain B (length=214) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RVPQNWFPIFNPLKIPLQRNVIPSVTRVLQQTMTKQQVFLLERWKQRMIL
ELGEDGFKEYTSNVFLQGKRFHEALESILSPSGYIESVQHILKDVSGVRA
LESAVQHETLNYIGLLDCVAEYQGKLCVIDWKTSEKPKPFIQSTFDNPLQ
VVAYMGAMNHDTNYSFQVQCGLIVVAYKDGSPAHPHFMDAELCSQYWTKW
LLRLEEYTEKKKNQ
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain8xa9 Chain B Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8xa9 Structural basis of how MGME1 processes DNA 5' ends to maintain mitochondrial genome integrity.
Resolution2.32 Å
Binding residue
(original residue number in PDB)		H180 D238 D251 W252
Binding residue
(residue number reindexed from 1)		H72 D117 D130 W131
Annotation score4
Enzymatic activity
Enzyme Commision number 3.1.-.-
External links
PDB RCSB:8xa9, PDBe:8xa9, PDBj:8xa9
PDBsum8xa9
PubMed38471810
UniProtQ9BQP7|MGME1_HUMAN Mitochondrial genome maintenance exonuclease 1 (Gene Name=MGME1)

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