Structure of PDB 8wa1 Chain B Binding Site BS04

Receptor Information
>8wa1 Chain B (length=998) Species: 4097 (Nicotiana tabacum) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NEGISTIPGFNQIQFEGFCRFIDQGLTEELYKFPKIEDTDQEIEFQLFVE
TYQLVEPLIKERDAVYESLTYSSELYVSAGLIWKNSRDMQEQTIFIGNIP
LMNSLGTSIVNGIYRIVINQILQSPGIYYRSELDHNGISVYTGTIISDWG
GRSELEIDRKARIWARVSRKQKISILVLSSAMGLNLREILENVCYPEIFL
SFLFFQQRCELGRIGRRNMNRRLNLDIPQNNTFLLPRDILAAADHLIGLK
FGMGALDDMNHLKNKRIRSVADLLQDQFGLALVRLENVVRGTICGAIRHK
LIPTPQNLVTSTPLTTTYESFFGLHPLSQVLDRTNPLTQIVHGRKLSYLG
PGGLTGRTASFRIRDIHPSHYGRICPIDTSEGINVGLIGSLAIHARIGHW
GSLESPFYEISERSTGVRMLYLSPGRDEYYMVAAGNSLALNQDIQEEQVV
PARYRQEFLTIAWEQVHLRSIFPFQYFSIGASLIPFIEHNDANRALMSSN
MQRQAVPLSRSEKCIVGTGLERQAALDSGALAIAEREGRVVYTNTDKILL
AGNGDILSIPLVIYQRSNKNTCMHQKLQVPRGKCIKKGQILADGAATVGG
ELALGKNVLVAYMPWEGYNSEDAVLISERLVYEDIYTSFHIRKYEIQTHV
TSQGPEKVTNEIPHLEAHLLRNLDKNGIVMLGSWVETGDILVGKLTPQSK
ETCLKLPIGGRGRVIDVRWIQKRGGSSYNPETIRVYILQKREIKVGDKVA
GRHGNKGIISKILPRQDMPYLQDGRSVDMVFNPLGVPSRMNVGQIFECSL
GLAGSLLDRHYRIAPFDERYEQEASRKLVFSELYEASKQTANPWVFEPEY
PGKSRIFDGRTGNPFEQPVIIGKPYILKLIHQVDDKIHGRSSGHYALVTQ
QPLRGRAKQGGQRVGEMEVWALEGFGVAHILQEMLTYKSDHIRARQEVLG
TTIIGGTIPNPEDAPESFRLLVRELRSLALELNHFLVSEKNFQINRKE
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8wa1 Chain B Residue 1101 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8wa1 Cryo-EM structures of the plant plastid-encoded RNA polymerase.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		E535 H536 D888 E889 S896
Binding residue
(residue number reindexed from 1)		E488 H489 D817 E818 S825
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0032549 ribonucleoside binding
GO:0034062 5'-3' RNA polymerase activity
Biological Process
GO:0006351 DNA-templated transcription
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0009507 chloroplast

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8wa1, PDBe:8wa1, PDBj:8wa1
PDBsum8wa1
PubMed38428393
UniProtP06271|RPOB_TOBAC DNA-directed RNA polymerase subunit beta (Gene Name=rpoB)

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