Structure of PDB 8w6c Chain B Binding Site BS04

Receptor Information
>8w6c Chain B (length=530) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MATCWQALWAYRSYLIVFFVPILLLPLPILVPSKEAYCAYAIILMALFWC
TEALPLAVTALFPLILFPMMGIVDASEVAVEYLKDSNLLFFGGLLVAIAV
EHWNLHKRIALRVLLIVGVRPAPLILGFMLVTAFLSMWISNTATSAMMVP
IAHAVLDQLHSSQAKHLHLTQCMSLCVCYSASIGGIATLTGTAPNLVLQG
QINSLFPQNGNVVNFASWFSFAFPTMVILLLLAWLWLQILFLGFNFRKNF
GIGEKMQEQQQAAYCVIQTEHRLLGPMTFAEKAISILFVILVLLWFTREP
GFFLGWGNLAFPNAKGESMVSDGTVAIFIGIIMFIIPSKFPGLTQDPENP
GKLKAPLGLLDWKTVNQKMPWNIVLLLGGGYALAKGSERSGLSEWLGNKL
TPLQSVPAPAIAIILSLLVATFTECTSNVATTTIFLPILASMAQAICLHP
LYVMLPCTLATSLAFMLPVATPPNAIVFSFGDLKVLDMARAGFLLNIIGV
LVIALAINSWGIPLFSLHSFPSWAQSNTTA
Ligand information
Ligand IDNA
InChIInChI=1S/Na/q+1
InChIKeyFKNQFGJONOIPTF-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
CACTVS 3.341
OpenEye OEToolkits 1.5.0		[Na+]
FormulaNa
NameSODIUM ION
ChEMBL
DrugBankDB14516
ZINC
PDB chain8w6c Chain B Residue 1103 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB8w6c Cryo-EM structures of the human NaS1 and NaDC1 transporters revealed the elevator transport and allosteric regulation mechanism.
Resolution2.7 Å
Binding residue
(original residue number in PDB)		T471 T474 S475 N476 A518
Binding residue
(residue number reindexed from 1)		T423 T426 S427 N428 A470
Annotation score5
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0015138 fumarate transmembrane transporter activity
GO:0015139 alpha-ketoglutarate transmembrane transporter activity
GO:0015141 succinate transmembrane transporter activity
GO:0015293 symporter activity
GO:0015361 low-affinity sodium:dicarboxylate symporter activity
GO:0015370 solute:sodium symporter activity
GO:0017153 sodium:dicarboxylate symporter activity
GO:0022857 transmembrane transporter activity
Biological Process
GO:0006814 sodium ion transport
GO:0015741 fumarate transport
GO:0015742 alpha-ketoglutarate transport
GO:0035725 sodium ion transmembrane transport
GO:0055085 transmembrane transport
GO:0071285 cellular response to lithium ion
GO:0071422 succinate transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016324 apical plasma membrane
GO:0070062 extracellular exosome

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8w6c, PDBe:8w6c, PDBj:8w6c
PDBsum8w6c
PubMed38552027
UniProtQ13183|S13A2_HUMAN Solute carrier family 13 member 2 (Gene Name=SLC13A2)

[Back to BioLiP]