Structure of PDB 8kaj Chain B Binding Site BS04 |
| >8kaj Chain B (length=1326) Species: 301447 (Streptococcus pyogenes serotype M1)
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KYSIGLAIGTNSVGWAVITDEYKVPSKKFKVLGNTDRHSIKKNLIGALLF
DSGETAEATRLKRTARRRYTRRKNRICYLQEIFSNEMAKVDDSFFHRLEE
SFLVEEDKKHERHPIFGNIVDEVAYHEKYPTIYHLRKKLVDSTDKADLRL
IYLALAHMIKFRGHFLIEGDLNPDNSDVDKLFIQLVQTYNQLFEENPINA
SGVDAKAILSARLSKSRRLENLIAQLPGEKKNGLFGNLIALSLGLTPNFK
SNFDLAEDAKLQLSKDTYDDDLDNLLAQIGDQYADLFLAAKNLSDAILLS
DILRVNTEITKAPLSASMIKRYDEHHQDLTLLKALVRQQLPEKYKEIFFD
QSKNGYAGYIDGGASQEEFYKFIKPILEKMDGTEELLVKLNREDLLRKQR
TFDNGSIPHQIHLGELHAILRRQEDFYPFLKDNREKIEKILTFRIPYYVG
PLARGNSRFAWMTRKSEETITPWNFEEVVDKGASAQSFIERMTNFDKNLP
NEKVLPKHSLLYEYFTVYNELTKVKYVTEGMRKPAFLSGEQKKAIVDLLF
KTNRKVTVKQLKEDYFKKIECFDSVEISGVEDRFNASLGTYHDLLKIIKD
KDFLDNEENEDILEDIVLTLTLFEDREMIEERLKTYAHLFDDKVMKQLKR
RRYTGWGRLSRKLINGIRDKQSGKTILDFLKSDGFANRNFMQLIHDDSLT
FKEDIQKAQVSGDSLHEHIANLAGSPAIKKGILQTVKVVDELVKVMGRHK
PENIVIEMARNSRERMKRIEEGIKELGSQILKEHPVENTQLQNEKLYLYY
LQNGRDMYVDQELDINRLSDYDVDAIVPQDDSIDNKVLTRSDKNRGKSDN
VPSEEVVKKMKNYWRQLLNAKLITQRKFDNLTKAERGGLSELDKAGFIKR
QLVETRQITKHVAQILDSRMNTKYDENDKLIREVKVITLKSKLVSDFRKD
FQFYKVREINNYHHAHDAYLNAVVGTALIKKYPKLESEFVYGDKVYDVRK
MAKYFFYSNIMNFFKTEITLKRPLIETNGETGEIVWDKGRDFATVRKVLS
MPQVNIVKKTEVQTGGFSKESILPKRNSDKLIARKKDWDPKKYGGFDSPT
VAYSVLVVAKVEKGKSKKLKSVKELLGITIMERSSFEKNPIDFLEAKGYK
EVKKDLIIKLPKYSLFELENGRKRMLASAGELQKGNELALPSKYVNFLYL
ASHYEKLKGSPEDNEQKQLFVEQHKHYLDEIIEQISEFSKRVILADANLD
KVLSAYNKHRDKPIREQAENIIHLFTLTNLGAPAAFKYFDTTIDRKRYTS
TKEVLDATLIHQSITGLYETRIDLSQ |
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| PDB | 8kaj Trans-nuclease activity of Cas9 activated by DNA or RNA target binding. |
| Resolution | 3.42 Å |
Binding residue
(original residue number in PDB) | K30 L35 R40 K44 N46 E57 T62 R69 R70 Y72 R74 N77 Y81 L101 S104 F105 T134 I135 H160 K163 Y325 H328 H329 L332 K336 R340 F351 F352 Y359 I363 K401 Q402 R403 L455 A456 R457 N459 S460 F462 T472 I473 P475 H721 K735 Q739 K742 P1090 K1097 E1099 V1100 G1103 G1104 F1105 R1122 K1123 K1124 F1134 M1169 E1225 L1226 A1227 Q1272 H1349 Q1350 S1351 Y1356 E1357 |
Binding residue
(residue number reindexed from 1) | K27 L32 R37 K41 N43 E54 T59 R66 R67 Y69 R71 N74 Y78 L98 S101 F102 T131 I132 H157 K160 Y322 H325 H326 L329 K333 R337 F348 F349 Y356 I360 K398 Q399 R400 L452 A453 R454 N456 S457 F459 T469 I470 P472 H716 K730 Q734 K737 P1052 K1059 E1061 V1062 G1065 G1066 F1067 R1084 K1085 K1086 F1096 M1131 E1187 L1188 A1189 Q1234 H1311 Q1312 S1313 Y1318 E1319 |
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