Structure of PDB 8kah Chain B Binding Site BS04 |
| >8kah Chain B (length=1322) Species: 301447 (Streptococcus pyogenes serotype M1)
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KYSIGLAIGTNSVGWAVITDEYKVPSKKFKVLGNTDRHSIKKNLIGALLF
DSGETAEATRLKRTARRRYTRRKNRICYLQEIFSNEMAKVDDSFFHRLEE
SFLVEEDKKHERHPIFGNIVDEVAYHEKYPTIYHLRKKLVDSTDKADLRL
IYLALAHMIKFRGHFLIEGDLNPDNSDVDKLFIQLVQTYNQLFEENPINA
SGVDAKAILSARLSKSRRLENLIAQLPGEKKNGLFGNLIALSLGLTPNFK
SNFDLAEDAKLQLSKDTYDDDLDNLLAQIGDQYADLFLAAKNLSDAILLS
DILRVNTEITKAPLSASMIKRYDEHHQDLTLLKALVRQQLPEKYKEIFFD
QSKNGYAGYIDGGASQEEFYKFIKPILEKMDGTEELLVKLNREDLLRKQR
TFDNGSIPHQIHLGELHAILRRQEDFYPFLKDNREKIEKILTFRIPYYVG
PLARGNSRFAWMTRKSEETITPWNFEEVVDKGASAQSFIERMTNFDKNLP
NEKVLPKHSLLYEYFTVYNELTKVKYVTEGMRKPAFLSGEQKKAIVDLLF
KTNRKVTVKQLKEDYFKKIECFDSVEISGVEDRFNASLGTYHDLLKIIKD
KDFLDNEENEDILEDIVLTLTLFEDREMIEERLKTYAHLFDDKVMKQLKR
RRYTGWGRLSRKLINGIRDKQSGKTILDFLKSDGFANRNFMQLIHDDSLT
FKEDIQKAQVSGDSLHEHIANLAGSPAIKKGILQTVKVVDELVKVMGRHK
PENIVIEMARNSRERMKRIEEGIKELGSQILKEHPVENTQLQNEKLYLYY
LQNGRDMYVDQELDINRLSDYDVDAIVPQDDSIDNKVLTRSDKNRGKSDN
VPSEEVVKKMKNYWRQLLNAKLITQRKFDNLTKAERGGLSELDKAGFIKR
QLVETRQITKHVAQILDSRMNTKYDENDKLIREVKVITLKSKLVSDFRKD
FQFYKVREINNYHHAHDAYLNAVVGTALIKKYPKLESEFVYGDKVYDVRK
MFYSNIMNFFKTEITLKRPLIETNGETGEIVWDKGRDFATVRKVLSMPQV
NIVKKTEVQTGGFSKESILPKRNSDKLIARKKDWDPKKYGGFDSPTVAYS
VLVVAKVEKGKSKKLKSVKELLGITIMERSSFEKNPIDFLEAKGYKEVKK
DLIIKLPKYSLFELENGRKRMLASAGELQKGNELALPSKYVNFLYLASHY
EKLKGSPEDNEQKQLFVEQHKHYLDEIIEQISEFSKRVILADANLDKVLS
AYNKHRDKPIREQAENIIHLFTLTNLGAPAAFKYFDTTIDRKRYTSTKEV
LDATLIHQSITGLYETRIDLSQ |
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| PDB | 8kah Trans-nuclease activity of Cas9 activated by DNA or RNA target binding. |
| Resolution | 3.36 Å |
Binding residue
(original residue number in PDB) | K30 L35 R40 K44 N46 E57 T62 R69 R70 Y72 R74 N77 Y81 L101 S104 T134 I135 H160 K163 Y325 H328 H329 L332 K336 R340 F351 F352 Y359 Q402 R403 L455 A456 R457 N459 S460 F462 R467 T472 I473 H721 K735 Q739 K742 R753 P1090 Q1091 K1097 E1099 V1100 T1102 G1103 G1104 F1105 R1122 K1123 F1134 M1169 E1225 L1226 A1227 P1229 Q1272 H1349 Q1350 S1351 Y1356 E1357 |
Binding residue
(residue number reindexed from 1) | K27 L32 R37 K41 N43 E54 T59 R66 R67 Y69 R71 N74 Y78 L98 S101 T131 I132 H157 K160 Y322 H325 H326 L329 K333 R337 F348 F349 Y356 Q399 R400 L452 A453 R454 N456 S457 F459 R464 T469 I470 H716 K730 Q734 K737 R748 P1048 Q1049 K1055 E1057 V1058 T1060 G1061 G1062 F1063 R1080 K1081 F1092 M1127 E1183 L1184 A1185 P1187 Q1230 H1307 Q1308 S1309 Y1314 E1315 |
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