Structure of PDB 8jx9 Chain B Binding Site BS04

Receptor Information
>8jx9 Chain B (length=1077) Species: 10116 (Rattus norvegicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PTRPPGMCHLDEFQCQGDGTCIPNTWECDGHPDCIHGSDEHTGCVPKTCG
HSVNTCRASQFQCDNGRCISGNWVCDGDNDCGDMSDEDQRHHCELQNCSS
TQFTCVNSRPPNRRCIPQYWVCDGDADCSDALDELQNCTMRTCSAGEFSC
ANGRCVRQSFRCDRRNDCGDYSDERGCSYPPCHANQFTCQNGRCIPRFFV
CDEDNDCGDGSDEQEHLCHTPEPTCPLHQFRCDNGHCIEMGRVCNHVDDC
SDNSDEKGCGINECLDSSISRCDHNCTDTITSFYCSCLPGYKLMSDKRSC
VDIDECKESPQLCSQKCENVVGSYICKCAPGYIREPDGKSCRQNSNIEPY
LIFSNRYYIRNLTTDGSSYSLILQGLGNVVALDFDRVEKRLYWIDAEKQI
IERMFLNKTNRETIINHRLRRAESLAVDWVSRKLYWLDAILDCLFVSDLE
GRHRKMIAQHCVDANNTFCFEHPRGIVLHPQRGHVYWADWGVHAYIGRIG
MDGTNKSVIISTKIEWPNAITIDYTNDLLYWADAHLGYIEFSDLEGHHRH
TVYDGSLPHPFALTIFEDTVFWTDWNTRTVEKGNKYDGSGRVVLVNTTHK
PFDIHVYHPYRQPIMSNPCGTNNGGCSHLCLIKAGGRGFTCACPDDFQTV
QLRDRTLCMPMCSSTQFLCGNNEKCIPIWWKCDGQKDCSDGSDEPDLCPH
RFCRLGQFQCRDGNCTSPQALCNARQDCADGSDEDRVLCEHHRCESNEWQ
CANKRCIPQSWQCDSVNDCLDNSDEDTSHCASRTCRPGQFKCNNGRCIPQ
SWKCDVDNDCGDYSDEPIDECTTAAYNCDNHTEFSCKTNYRCIPQWAVCN
GFDDCRDNSDEQGCESVPCHPSGDFRCANHHCIPLRWKCDGTDDCGDNSD
EENCVPRECSESEFRCADQQCIPSRWVCDQENDCGDNSDERDCEMKTCHP
EHFQCTSGHCVPKALACDGRADCLDASDESACPTRFPNGTYCPAAMFECK
NHVCIQSFWICDGENDCVDGSDEEIHLCFNIPCESPQRFRCDNSRCVYGH
QLCNGVDDCGDGSDEKEEHCRKPTHKP
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain8jx9 Chain B Residue 4710 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8jx9 Cryo-EM structures elucidate the multiligand receptor nature of megalin.
Resolution3.8 Å
Binding residue
(original residue number in PDB)		W2972 D2975 D2977 D2979 D2985 E2986
Binding residue
(residue number reindexed from 1)		W120 D123 D125 D127 D133 E134
Annotation score4
External links
PDB RCSB:8jx9, PDBe:8jx9, PDBj:8jx9
PDBsum8jx9
PubMed38771880
UniProtP98158|LRP2_RAT Low-density lipoprotein receptor-related protein 2 (Gene Name=Lrp2)

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