Structure of PDB 8ile Chain B Binding Site BS04

Receptor Information

>8ile Chain B (length=176) Species: 10498 (African swine fever virus BA71V)

GGMLTLIQGKKIVNHLRSRLAFEYNGQLIKILSKNIVAVGSLRREEKMLN
DVDLLIIVPEKKLLKHVLPNIRIKGLSFSVKVCGERKCVLFIEWEKKTYQ
LDLFTALAEEKPYAIFHFTGPVSYLIRIRAALKKKNYKLNQYGLFKNQTL
VPLKITTEKELIKELGFTYRIPKKRL

Ligand information

• Ligand ID: MN
• InChI: InChI=1S/Mn/q+2
• InChIKey: WAEMQWOKJMHJLA-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mn+2]
  CACTVS 3.341: [Mn++]
• Formula: Mn
• Name: MANGANESE (II) ION
• DrugBank: DB06757
• PDB chain: 8ile Chain B Residue 202

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8ile Structural Insight into Polymerase Mechanism via a Chiral Center Generated with a Single Selenium Atom.
• Resolution: 3.0 Å
• Binding residue (original residue number in PDB): D49 D51 D100
• Binding residue (residue number reindexed from 1): D51 D53 D102
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 2.7.7.7: DNA-directed DNA polymerase.

Gene Ontology

Molecular Function

• GO:0003677 DNA binding
• GO:0003887 DNA-directed DNA polymerase activity
• GO:0016779 nucleotidyltransferase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006259 DNA metabolic process
• GO:0006281 DNA repair
• GO:0006303 double-strand break repair via nonhomologous end joining
• GO:0071897 DNA biosynthetic process

Cellular Component

• GO:0044423 virion component

External links

• PDB: RCSB:8ile, PDBe:8ile, PDBj:8ile
• PDBsum: 8ile
• PubMed: 37958741
• UniProt: P42494|DPOLX_ASFB7 Repair DNA polymerase X (Gene Name=Ba71V-97)