Structure of PDB 8iab Chain B Binding Site BS04

Receptor Information
>8iab Chain B (length=704) Species: 3702 (Arabidopsis thaliana) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TPLALVGAKVSHIESLDYEINENDLFKHDWRSRSKAQVFQYIFLKWTLAC
LVGLFTGLIATLINLAVENIAGYKLLAVGYYIAQDRFWTGLMVFTGANLG
LTLVATVLVVYFAPTAAGPGIPEIKAYLNGIDTPNMFGFTTMMVKIVGSI
GAVAAGLDLGKEGPLVHIGSCIASLLGQGGPDNHRIKWRWLRYFNNDRDR
RDLITCGSASGVCAAFRSPVGGVLFALEEVATWWRSALLWRTFFSTAVVV
VVLRAFIEICNSGKCGLFGSGGLIMFDVSHVEVRYHAADIIPVTLIGVFG
GILGSLYNHLLHKVLRLYNLINQKGKIHKVLLSLGVSLFTSVCLFGLPFL
AECKPCKQFNCPNGYYNDLSTLLLTTNDDAVRNIFSSNTPNEFGMVSLWI
FFGLYCILGLITFGIATPSGLFLPIILMGSAYGRMLGTAMGSYTNIDQGL
YAVLGAASLMAGSMRMTVSLCVIFLELTNNLLLLPITMFVLLIAKTVGDS
FNLSIYEIILHLKGLPFLEANPEPWMRNLTVGELNDAKPPVVTLNGVEKV
ANIVDVLRNTTHNAFPVLDGGTELHGLILRAHLVKVLKKRWFLNEKRRTE
EWEVREKFTPVELAEREDNFDDVAITSSEMQLYVDLHPLTNTTPYTVVQS
MSVAKALVLFRSVGLRHLLVVPKIQASGMSPVIGILTRQDLRAYNILQAF
PHLD
Ligand information
Ligand IDCL
InChIInChI=1S/ClH/h1H/p-1
InChIKeyVEXZGXHMUGYJMC-UHFFFAOYSA-M
SMILES
SoftwareSMILES
ACDLabs 10.04
CACTVS 3.341
OpenEye OEToolkits 1.5.0		[Cl-]
FormulaCl
NameCHLORIDE ION
ChEMBL
DrugBankDB14547
ZINC
PDB chain8iab Chain B Residue 803 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8iab Molecular mechanism underlying regulation of Arabidopsis CLCa transporter by nucleotides and phospholipids.
Resolution2.96 Å
Binding residue
(original residue number in PDB)		G201 E203 G478
Binding residue
(residue number reindexed from 1)		G160 E162 G420
Annotation score5
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005247 voltage-gated chloride channel activity
GO:0005254 chloride channel activity
GO:0005515 protein binding
GO:0015112 nitrate transmembrane transporter activity
Biological Process
GO:0006821 chloride transport
GO:0010167 response to nitrate
GO:0015706 nitrate transmembrane transport
GO:0034220 monoatomic ion transmembrane transport
GO:0055085 transmembrane transport
GO:1902476 chloride transmembrane transport
Cellular Component
GO:0016020 membrane
GO:0034707 chloride channel complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8iab, PDBe:8iab, PDBj:8iab
PDBsum8iab
PubMed37573431
UniProtP92941|CLCA_ARATH Chloride channel protein CLC-a (Gene Name=CLC-A)

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