Structure of PDB 8e4x Chain B Binding Site BS04

Receptor Information

>8e4x Chain B (length=454) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

NPVMILNELRPGLKYDFLSESGESHAKSFVMSVVVDGQFFEGSGRNKKLA
KARAAQSALAAIFNLHLDQTPSRQPIPSEGLQLHLPQVLADAVSRLVLGK
FGDLTDNFSSPHARRKVLAGVVMTTGTDVKDAKVISVSTGTKCINGEYMS
DRGLALNDCHAEIISRRSLLRFLYTQLELYLNNKDDQKRSIFQKSERGGF
RLKENVQFHLYISTSPCGDARIFSPHEPIARGQLRTKIESGQGTIPVRSN
ASIQTWDGVLQGERLLTMSCSDKIARWNVVGIQGSLLSIFVEPIYFSSII
LGSLYHGDHLSRAMYQRISNIEDLPPLYTLNKPLLSGISNAEARQPGKAP
NFSVNWTVGDSAIEVINATTGKDELGRASRLCKHALYCRWMRVHGKVPSH
LLRSKITKPNVYHESKLAAKEYQAAKARLFTAFIKAGLGAWVEKPTEQDQ
FSLT

Ligand information

Ligand ID

InChI

InChI=1S/Zn/q+2

InChIKey

PTFCDOFLOPIGGS-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Zn++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Zn+2]

Formula

Name

ZINC ION

PDB chain

8e4x Chain B Residue 802 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8e4x ADAR activation by inducing a syn conformation at guanosine adjacent to an editing site.
Resolution	2.8 Å
Binding residue (original residue number in PDB)	H394 C451 C516
Binding residue (residue number reindexed from 1)	H160 C217 C270
Annotation score	1

Enzymatic activity

Enzyme Commision number

3.5.4.37: double-stranded RNA adenine deaminase.

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0004000	adenosine deaminase activity

	Biological Process
GO:0006396	RNA processing

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Molecular Function

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Biological Process

External links

PDB	RCSB:8e4x, PDBe:8e4x, PDBj:8e4x
PDBsum	8e4x
PubMed	36243986
UniProt	P78563\|RED1_HUMAN Double-stranded RNA-specific editase 1 (Gene Name=ADARB1)

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