Structure of PDB 8cls Chain B Binding Site BS04

Receptor Information
>8cls Chain B (length=853) Species: 7227 (Drosophila melanogaster) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NVKPCKSMDIRNMVSHFNQLENCTVIEGFLLIDLINDASPLNRSFPKLTE
VTDYIIIYRVTGLHSLSKIFPNLSVIRGNKLFDGYALVVYSNFDLMDLGL
HKLRSITRGGVRIEKNHKLCYDRTIDWLEILAENETQLVVLTENGKEKEC
RLSKCPGEIRSCQLHNNRRLCWNSKLCQTKCPEKCRNNCIDEHTCCSQDC
LGGCVIDKNGNESCISCRNVSFNNICMDSCPKGYYQFDSRCVTANECITL
TKFETNSVYSGIPYNGQCITHCPTGYQKSENKRMCEPCPGGKCDKECSSG
LIDSLERAREFHGCTIITGTEPLTISIKRESGAHVMDELKYGLAAVHKIQ
SSLMVHLTYGLKSLKFFQSLTEISGDPPMDADKYALYVLDNRDLDELWGP
NQTVFIRKGGVFFHFNPKLCVSTINQLLPMLASKPKFFEKSDVGADSNGN
RGSCGTAVLNVTLQSVGANSAMLNVTTKVEIGEPQKPSNATIVFKDPRAF
IGFVFYHMIDPYGNSTKSSDDPCDDRWKVSSPEKSGVMVLSNLIPYTNYS
YYVRTMAISSELTNAESDVKNFRTNPGRPSKVTEVVATAISDSKINVTWS
YLDKPYGVLTRYFIKAKLINRPTRNNNRDYCTEPLVEYDDRKVQAGMEFE
NALQNFIFVPKDDENTYKDEEDLSSNKQFYEVFAKELPPNQTHFVFEKLR
HFTRYAIFVVACREEIPSEKLRDTSFKKSLCSDYDTVFQTTKRKKFADIV
MDLKVDLEHANNTESPVRVRWTPPVDPNGEIVTYEVAYKLQKPDQVEEKK
CIPAADFNQTAGYLIKLNEGLYSFRVRANSIAGYGDFTEVEHIKVEPPPS
YAK
Ligand information
>8cls Chain H (length=26) Species: 7227 (Drosophila melanogaster) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
SLRACGPALMDMLRVACPNGFNSMFA
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8cls Structural conservation of insulin/IGF signalling axis at the insulin receptors level in Drosophila and humans.
Resolution4.0 Å
Binding residue
(original residue number in PDB)		R848 E1036 Q1040 F1042 F1044 V1045
Binding residue
(residue number reindexed from 1)		R498 E650 Q654 F656 F658 V659
Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
External links
PDB RCSB:8cls, PDBe:8cls, PDBj:8cls
PDBsum8cls
PubMed37805602
UniProtP09208|INSR_DROME Insulin-like receptor (Gene Name=InR)

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