Structure of PDB 6p2o Chain B Binding Site BS04

Receptor Information
>6p2o Chain B (length=727) Species: 1343740 (Streptomyces rapamycinicus NRRL 5491) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DAYTWKNVRVDGGGFVPGIVFNRKEKNLAYARTDIGGAYRWDQSGKRWVP
LLDSLDWDHWGWTGVVSLASDSVDPNKVYVAAGTYTNSWDPGNGAILRSS
NRGASWQSTTLPFKLGGNMPGRGMGERLAVDPNRNSVLYLGAPSGNGLWR
STDSGMTWSKVTSFPNPGTYVQDASDTSGYLSDNQGVVWVTFDERTGSSG
SATKTIYVGVADKDNTVYRSTDAGVTWSRVAGQPTGYLSHKGVLDAKDGY
LYLTTSDKGGPYDGEKGQVWRYTTATGEWKNISPMADADTYFGYSGLTVD
RQKPGTLMVTGYSSWWPDTQIFRSTDSGATWTRAWDFTSYPNRSLRYTQD
VSSVPWLTFGTNPTPPEVTPKLGWMTEALEIDPFDSNRMMYGTGATVYGT
ENLGNWDTGGKIAITPMIRGLEETAVNDLASPPTGAPLLSALGDIGGFRH
TDLDAVPARMYTSPTFTTTTSLDYAETNPNTVVRVGNNDSAPRIAFSTDN
GANWFQGSEPSGVTGGGTVAAAADGSGFVWAPEGSSAVYHTTGFGNSWSV
SSGIPAGAVVESDRKNPKKFYGFKAGTFYVSTDGGATFTARASSGLPADG
PARFKALPGAEGDIWLAGGSTGGAYGLWHSTDSGATFTKLSGVQQADTIG
FGKAAPGASYQTLYTSAKIGGVRGVFRSTDAGASWTRINDDAHQWGWTGA
SITGDPRVYGRVYVATNGRGILRGDIS
Ligand information
Ligand IDXYS
InChIInChI=1S/C5H10O5/c6-2-1-10-5(9)4(8)3(2)7/h2-9H,1H2/t2-,3+,4-,5+/m1/s1
InChIKeySRBFZHDQGSBBOR-LECHCGJUSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0C1C(C(C(C(O1)O)O)O)O
CACTVS 3.341O[CH]1CO[CH](O)[CH](O)[CH]1O
OpenEye OEToolkits 1.5.0C1[C@H]([C@@H]([C@H]([C@H](O1)O)O)O)O
CACTVS 3.341O[C@@H]1CO[C@H](O)[C@H](O)[C@H]1O
ACDLabs 10.04OC1C(O)COC(O)C1O
FormulaC5 H10 O5
Namealpha-D-xylopyranose;
alpha-D-xylose;
D-xylose;
xylose;
XYLOPYRANOSE
ChEMBL
DrugBankDB03389
ZINCZINC000001529214
PDB chain6p2o Chain E Residue 8 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6p2o Substrate specificity, regiospecificity, and processivity in glycoside hydrolase family 74.
Resolution1.88 Å
Binding residue
(original residue number in PDB)		Y225 Y307
Binding residue
(residue number reindexed from 1)		Y180 Y262
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0016798 hydrolase activity, acting on glycosyl bonds
Biological Process
GO:0000272 polysaccharide catabolic process
GO:0010411 xyloglucan metabolic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6p2o, PDBe:6p2o, PDBj:6p2o
PDBsum6p2o
PubMed31324716
UniProtA0A0A0NH71

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