Structure of PDB 6p07 Chain B Binding Site BS04

Receptor Information
>6p07 Chain B (length=303) Species: 7227 (Drosophila melanogaster) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VVSVKGVEQKLVQLILDEIVEGGAKVEWTDIAGQDVAKQALQEMVILPSV
RPELFTGLRAPAKGLLLFGPPGNGKTLLARAVATECSATFLNISAASLTS
KYVGDGEKLVRALFAVARHMQPSIIFIDQVDSLLSERSSSEHEASRRLKT
EFLVEFDGLPGNPDGDRIVVLAATNRPQELDEAALRRFTKRVYVSLPDEQ
TRELLLNRLLQKQGSPLDTEALRRLAKITDGYSGSDLTALAKDAALEPIR
ELNVEQVKCLDISAMRAITEQDFHSSLKRIRRSVAPQSLNSYEKWSQDYG
DIT
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain6p07 Chain B Residue 802 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6p07 An allosteric network in spastin couples multiple activities required for microtubule severing.
Resolution3.2 Å
Binding residue
(original residue number in PDB)		T530 D582
Binding residue
(residue number reindexed from 1)		T76 D128
Annotation score1
Enzymatic activity
Enzyme Commision number 5.6.1.1: microtubule-severing ATPase.
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0008568 microtubule severing ATPase activity
GO:0016887 ATP hydrolysis activity

View graph for
Molecular Function
External links
PDB RCSB:6p07, PDBe:6p07, PDBj:6p07
PDBsum6p07
PubMed31285604
UniProtA0A0B4LHJ5

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